Search
Now showing items 1-10 of 14
Strategies for Temporal and Spectral Imaging with X-ray Computed Tomography
(2012)
X-ray micro-CT is widely used for small animal imaging in preclinical studies of cardiopulmonary
disease, but further development is needed to improve spatial resolution, temporal
resolution, and material contrast. This ...
Techniques for Quantitation of Left Ventricular Volume in Ultrasound Using 4DViz
(2012)
In the United States, heart failure is a leading cause of hospitalization. The medical
industry places great emphasis on diagnosing heart disease through cardiac metrics
like ejection fraction. Left ventricular ejection ...
Magnetic Resonance Imaging Biomarkers of Renal Structure and Function
(2014)
The kidney's major role in filtration depends on its high blood flow, concentrating
mechanisms, and biochemical activation. The kidney's greatest strengths also lead
to vulnerability for drug-induced nephrotoxicity and other ...
Identifying Vulnerable Plaques with Acoustic Radiation Force Impulse Imaging
(2014)
The rupture of arterial plaques is the most common cause of ischemic complications
including stroke, the fourth leading cause of death and number one cause of long term
disability in the United States. Unfortunately, because ...
High-Resolution Diffusion Tensor Imaging and Human Brain Connectivity
(2013)
Diffusion tensor imaging (DTI) has emerged as a unique method to characterize brain
tissue microstructure non-invasively. DTI typically provides the ability to study
white matter structure with a standard voxel resolution ...
Chronic Myocardial Infarct Visualization Using 3D Ultrasound
(2011)
This dissertation aims to demonstrate the feasibility of direct infarct visualization
using 3D medical ultrasound. The dissertation proceeds by providing the first ever
demonstration of fully-sampled 3D ultrasonic speckle ...
Exploring Optical Contrast in Ex-Vivo Breast Tissue Using Diffuse Reflectance Spectroscopy and Tissue Morphology
(2012)
In 2011, an estimated 230,480 new cases of invasive breast cancer were diagnosed among
women, as well as an estimated 57,650 additional cases of in situ breast cancer [1].
Breast conserving surgery (BCS) is a recommended ...
Transthoracic Cardiac Acoustic Radiation Force Impulse Imaging
(2013)
This dissertation investigates the feasibility of a real-time transthoracic Acoustic
Radiation Force Impulse (ARFI) imaging system to measure myocardial function non-invasively
in clinical setting. Heart failure is an important ...
Delivery of Myoglobin Polymersomes Results in Tumor Hemorrhagic Necrosis and Enhanced Radiation Response
(2015)
There is a critical need to target tumor hypoxia as patients with hypoxic tumors have
worse prognosis due to aggressive phenotypes and resistance to radiotherapy and chemotherapy.
The overall goal of this work is to improve ...
Diffusion Tensor Imaging Biomarkers of Brain Development and Disease
(2014)
Understanding the structure of the brain has been a major goal of neuroscience research
over the past century, driven in part by the understanding that brain structure closely
follows function. Normative brain maps, or atlases, ...