Now showing items 1-5 of 5
MicroRNA Function in Cellular Stress Response
MicroRNAs are key post-transcriptional regulators that have been found to play critical roles in the regulation of cellular functions. There is an emerging concept that microRNAs may be just as essential for fine-tuning ...
Genetic Dissection of the Biological and Molecular Role of IDH1 Mutations in Glioma
Gliomas are tumors of the central nervous system for which improvements in treatment are critically needed. Mutations in IDH1 and IDH2, which encode the cytosolic and mitochondrial NADP+-dependent isocitrate dehydrogenases, ...
The Roles of Swe1p Localization and Feedback in the Regulation of the Morphogenesis Checkpoint
Saccharomyces cerevisiae cells exposed to a variety of physiological stresses transiently delay bud emergence or bud growth. To maintain coordination between bud formation and the cell cycle in such circumstances, ...
Epigenomic Mechanisms of Centromere Function and Chromosome Rearrangements
The centromere is essential for chromosome segregation and genome stability. It is the site of kinetochore assembly and chromosome attachment to the spindle microtubules, and it is important for chromosome movement during ...
The Molecular Structures of Recombination Intermediates in Yeast
The genetic information necessary for the survival and propagation of a species is contained within a physical structure, DNA. However, this molecule is sensitive to damage arising from both exogenous and endogenous sources. ...