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Genetic Control of Genomic Alterations Induced in Yeast by Interstitial Telomeric Sequences
Telomeric sequences are often located internally on the chromosome in addition to their usual positions at the ends of the chromosome. These internally-located telomeric sequences have been termed “interstitial telomeric ...
The Glucocorticoid-Mediated Dynamics of Genome Architecture
Human cells are perpetually receiving and responding to a variety of intrinsic and extrinsic signals. A primary mechanism by which cells carry out these responses is via changes in the regulation of gene expression. Many ...
Mechanisms of Protein Localization in Cryptococcus neoformans Mediate Virulence and Immune Recognition
Cryptococcus neoformans is an opportunistic fungal pathogen that causes significant disease and death in immunocompromised populations, in particular among those with advanced HIV infection. This fungus is found ubiquitously ...
Genomic and Epigenomic Attributes of Alpha Satellite Underlying Function Within the Human Centromere Region
The centromere serves as the foundation for the kinetochore and attachment point for spindle microtubules during metaphase. The proper function of this locus is required to ensure chromosome segregation and genomic stability. ...
Metabolic Regulation of Kelch-like Proteins Through O-glycosylation
O-GlcNAcylation is a reversible post-translational modification that decorates an O-linked ß-N-acetylglucosamine (O-GlcNAc) moiety onto the serine/threonine residues of target proteins. In mammals, this modification is regulated ...
Chemical and Genetic Modulation of the Host Immune Response to Mycobacterial Infection
Mycobacterium tuberculosis (Mtb) is the causative agent of the disease tuberculosis, which kills more people worldwide than any other infectious disease. In 2017, nearly 2 million people died of tuberculosis. Despite the ...