Now showing items 1-4 of 4
The Glucocorticoid-Mediated Dynamics of Genome Architecture
Human cells are perpetually receiving and responding to a variety of intrinsic and extrinsic signals. A primary mechanism by which cells carry out these responses is via changes in the regulation of gene expression. Many ...
The role of H3.3K27M-induced gene repression in brainstem gliomagenesis
Diffuse Intrinsic Pontine Glioma (DIPG) is a highly aggressive pediatric brainstem tumor recently found to contain high incidence of H3.3K27M mutations. These mutations reprogram the H3K27me3 epigenetic landscape of DIPG ...
Quantifying Eukaryotic Gene Regulation in Hormone Response and Disease.
Quantifying the function of mammalian enhancers at the genome or population scale has been longstanding challenge in the field of gene regulation. Studies of individual enhancers have provided anecdotal evidence on which ...
Population Sequencing for Studying Natural and Artifcial Variation in C. elegans
The advent of high coverage and low cost sequencing technologies has allowed fornewer and more powerful approaches in molecular and population genetics. Transposonsequencing, where genome-saturated mutant populations allele ...