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Topoisomerase 1-dependent Mutagenesis in Saccharomyces cerevisiae
Topoisomerase 1 (Top1) resolves transcription-associated supercoils by generating transient single-strand breaks in DNA and is a major source of transcription-associated mutagenesis in Saccharomyces cerevisiae. Top1 generates ...
Epigenetic Basis of Centromere Maintenance and Inheritance
Centromeres are essential chromosomal loci at which kinetochore formation occurs for spindle fiber attachment during mitosis and meiosis, guiding proper segregation of chromosomes. In humans, centromeres are located at large ...
Understanding the Effects of Genetic Variation on Osmo-adaptation Dynamics Across S. cerevisiae using Bulk Segregant Analysis and Whole Genome Sequencing
Adapting to environmental changes (i.e. an increase in osmolarity) is critical for cell survival. How cells respond and adapt to osmotic stress has been well-studied in the model eukaryote Saccharomyces cerevisiae. Although ...
Dynamic Regulation of Metabolism in Archaea
The regulation of metabolism is one of the key challenges faced by organisms across all domains of life. Despite fluctuating environments, cells must produce the same metabolic outputs to thrive. Although much is known about ...
Post-transcriptional Regulation of Cancer Traits and Gene Expression in a Genetically Defined, Primary Cell-derived Model of Breast Tumorigenesis
Post-transcriptional events are crucial determinants of gene expression, and aberrant expression patterns resulting from misregulation are evident in many pathological states. Cancer has traditionally been viewed as being ...