Show simple item record Rangnekar, Abhijit en_US Carter, Joshua en_US Labean, Thomas en_US 2011-06-21T17:26:00Z 2011-06-21T17:26:00Z 2010 en_US
dc.identifier.citation Hansen,Majken N.;Zhang,Alex M.;Rangnekar,Abhijit;Bompiani,Kristin M.;Carter,Joshua D.;Gothelf,Kurt V.;LaBean,Thomas H.. 2010. Weave Tile Architecture Construction Strategy for DNA Nanotechnology. Journal of the American Chemical Society 132(41): 14481-14486. en_US
dc.identifier.issn 0002-7863 en_US
dc.description.abstract Architectural designs for DNA nanostructures typically fall within one of two broad categories: tile-based designs (assembled from chemically synthesized oligonucleotides) and origami designs (woven structures employing a biological scaffold strand and synthetic staple strands). Both previous designs typically contain many Holliday-type multi-arm junctions. Here we describe the design, implementation, and testing of a unique architectural strategy incorporating some aspects of each of the two previous design categories but without multi-arm junction motifs. Goals for the new design were to use only chemically synthesized DNA, to minimize the number of component strands, and to mimic the back-and-forth, woven strand routing of the origami architectures. The resulting architectural strategy employs "weave tiles" formed from only two oligonucleotides as basic building blocks, thus decreasing the burden of matching multiple strand stoichiometries compared to previous tile-based architectures and resulting in a structurally flexible tile. As an example application, we have shown that the four-helix weave tile can be used to increase the anticoagulant activity of thrombin-binding aptamers in vitro. en_US
dc.language.iso en_US en_US
dc.publisher AMER CHEMICAL SOC en_US
dc.relation.isversionof doi:10.1021/ja104456p en_US
dc.subject crossover complexes en_US
dc.subject protein arrays en_US
dc.subject human thrombin en_US
dc.subject nanostructures en_US
dc.subject aptamer en_US
dc.subject molecules en_US
dc.subject design en_US
dc.subject bind en_US
dc.subject organization en_US
dc.subject nanotubes en_US
dc.subject chemistry, multidisciplinary en_US
dc.title Weave Tile Architecture Construction Strategy for DNA Nanotechnology en_US
dc.title.alternative en_US
dc.description.version Version of Record en_US 2010-10-20 en_US
duke.description.endpage 14486 en_US
duke.description.issue 41 en_US
duke.description.startpage 14481 en_US
duke.description.volume 132 en_US
dc.relation.journal Journal of the American Chemical Society en_US

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