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Distributions of Parameters and Features of Multiple Bond Ruptures in Force Spectroscopy by Atomic Force Microscopy

dc.contributor.author Guo, S
dc.contributor.author Li, N
dc.contributor.author Lad, N
dc.contributor.author Desai, S
dc.contributor.author Akhremitchev, BB
dc.date.accessioned 2011-06-21T17:26:38Z
dc.date.available 2011-06-21T17:26:38Z
dc.date.issued 2010
dc.identifier.citation Guo,Senli;Li,Nan;Lad,Nimit;Desai,Shivam;Akhremitchev,Boris B.. 2010. Distributions of Parameters and Features of Multiple Bond Ruptures in Force Spectroscopy by Atomic Force Microscopy. Journal of Physical Chemistry C 114(19): 8755-8765.
dc.identifier.issn 1932-7447
dc.identifier.uri https://hdl.handle.net/10161/4065
dc.description.abstract Force spectroscopy measurement of rupture forces of bound molecules becomes an important physicochemical tool in characterizing intermolecular interactions, Atomic force microscopy (AFM) measurements are among the most common approaches in implementation of this technique. Kinetic information about the molecular bond under study is usually extracted assuming that the detected rupture force comes from rupturing of a single bond. However, multiple bond ruptures might occur in experiments. In this article, we consider how the presence of multiple bonds is manifested in the distribution of parameters that are typically extracted in force spectroscopy experiments. Of particular interest here are the distributions of rupture forces and Kuhn lengths of polymeric tethers. We show that multiple bond ruptures might contribute to the measured distributions even when these distributions have a well-defined single peak. Also, we consider how the probability to form multiple bonds depends on probe velocity. The developed analytical models are applied to experimental data of biotin streptavidin ruptures. The velocity dependence of the amplitude of high force tail supports the hypothesis of multiple bond nature of the measured high forces.
dc.language.iso en_US
dc.publisher American Chemical Society (ACS)
dc.relation.isversionof 10.1021/jp100543u
dc.subject molecular adhesion
dc.subject systematic-errors
dc.subject energy landscapes
dc.subject single
dc.subject kinetics
dc.subject biotin
dc.subject afm
dc.subject strength
dc.subject dissociation
dc.subject mechanics
dc.subject chemistry, physical
dc.subject nanoscience & nanotechnology
dc.subject materials science, multidisciplinary
dc.title Distributions of Parameters and Features of Multiple Bond Ruptures in Force Spectroscopy by Atomic Force Microscopy
dc.title.alternative
dc.type Other article
dc.description.version Version of Record
duke.date.pubdate 2010-5-20
duke.description.issue 19
duke.description.volume 114
dc.relation.journal Journal of Physical Chemistry C
pubs.begin-page 8755


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