Show simple item record Peles, Dana N. en_US Simon, John D. en_US 2011-06-21T17:26:39Z 2011-06-21T17:26:39Z 2010 en_US
dc.identifier.citation Peles,Dana N.;Simon,John D.. 2010. The Ultraviolet Absorption Coefficient of Melanosomes Decreases with Increasing Pheomelanin Content. Journal of Physical Chemistry B 114(29): 9677-9683. en_US
dc.identifier.issn 1520-6106 en_US
dc.description.abstract Uveal melanosomes from the iridal stroma contain both eumelanin and pheomelanin, the ratio of which varies with iris color. Herein, we report the absorption coefficient at lambda = 244 nm for individual human iridal stroma melanosomes from dark brown and blue-green irides. The melanosomes are nearly identical in size, but differ in the relative concentration composition, ranging from a eumelanin/pheomelanin ratio of 14.8:1 (dark brown) to 1.3:1 (blue-green or hazel). The absorption coefficient of the melanosome decreases as its pheomelanin content increases. The origin of this decrease is attributed to a corresponding decrease in the number of UV-absorbing chromophores, reflecting the different molecular volumes of the monomeric building blocks of the two pigments. In agreement with reported data on synthetic pigments, the absorption coefficient of pheomelanin is found to be slightly larger than that for eumelanin at lambda = 244 nm (by a factor of 1.2). On the basis of the reported optical properties of synthetic models, this result suggests that the absorption of pheomelanin is less than eumelanin at wavelengths of biological relevance (similar to 315-400 nm). en_US
dc.language.iso en_US en_US
dc.publisher AMER CHEMICAL SOC en_US
dc.relation.isversionof doi:10.1021/jp102603b en_US
dc.subject photoinduced oxygen-consumption en_US
dc.subject chemical-properties en_US
dc.subject human hair en_US
dc.subject transient absorption en_US
dc.subject physical-properties en_US
dc.subject human melanocytes en_US
dc.subject melanin en_US
dc.subject systems en_US
dc.subject ocular melanin en_US
dc.subject quantum yields en_US
dc.subject action spectra en_US
dc.subject chemistry, physical en_US
dc.title The Ultraviolet Absorption Coefficient of Melanosomes Decreases with Increasing Pheomelanin Content en_US
dc.title.alternative en_US
dc.description.version Version of Record en_US 2010-7-29 en_US
duke.description.endpage 9683 en_US
duke.description.issue 29 en_US
duke.description.startpage 9677 en_US
duke.description.volume 114 en_US
dc.relation.journal Journal of Physical Chemistry B en_US

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