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Ultraviolet Absorption Coefficients of Melanosomes Containing Eumelanin As Related to the Relative Content of DHI and DHICA

dc.contributor.author Peles, Dana N
dc.contributor.author Lin, Erica
dc.contributor.author Wakamatsu, Kazumasa
dc.contributor.author Ito, Shosuke
dc.contributor.author Simon, John D
dc.date.accessioned 2011-06-21T17:26:44Z
dc.date.available 2011-06-21T17:26:44Z
dc.date.issued 2010
dc.identifier.citation Peles,Dana N.;Lin,Erica;Wakamatsu,Kazumasa;Ito,Shosuke;Simon,John D.. 2010. Ultraviolet Absorption Coefficients of Melanosomes Containing Eumelanin As Related to the Relative Content of DHI and DHICA. Journal of Physical Chemistry Letters 1(15): 2391-2395.
dc.identifier.issn 1948-7185
dc.identifier.uri https://hdl.handle.net/10161/4080
dc.description.abstract Central to understanding the photochemical function(s) of melanosomes is the determination of their absorption properties and an understanding of how the absorption varies with the molecular composition of melanin. Herein, the absorption coefficients for melanosomes containing predominantly eumelanin, a polymeric pigment derived from the molecular precursors 5,6-dihydroxyindole (DHI) and 5,6-dihydroxyindole-2-carboxylic acid (DHICA), are reported for) lambda = 244 nm. The absorption coefficient varies with the DHICA/DHI ratio, determined from chemical degradation analyses. With increasing DHICA content, the absorption coefficient of the melanosome increases. This observation is consistent with reported extinction coefficients, which reveal that at 244 nm, the extinction coefficient of DHICA is a factor of similar to 2.1 greater than that of DHI. The melanosome absorption coefficients are compared to predicted values based on a linear combination of the absorption of the constituent monomers.
dc.language.iso en_US
dc.publisher American Chemical Society (ACS)
dc.relation.isversionof 10.1021/jz100720h
dc.subject retinal-pigment epithelium
dc.subject 5,6-dihydroxyindole-2-carboxylic acid
dc.subject dopachrome tautomerase
dc.subject chemical-properties
dc.subject melanin
dc.subject oligomers
dc.subject threshold
dc.subject skin
dc.subject chemistry, physical
dc.subject nanoscience & nanotechnology
dc.subject materials science, multidisciplinary
dc.subject physics, atomic, molecular & chemical
dc.title Ultraviolet Absorption Coefficients of Melanosomes Containing Eumelanin As Related to the Relative Content of DHI and DHICA
dc.title.alternative
dc.type Other article
dc.description.version Version of Record
duke.date.pubdate 2010-8-5
duke.description.issue 15
duke.description.volume 1
dc.relation.journal Journal of Physical Chemistry Letters
pubs.begin-page 2391
pubs.end-page 2395


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