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Calcium Dependence of Fibrin Nanomechanics: The gamma 1 Calcium Mediates the Unfolding of Fibrinogen Induced by Force Applied to the "A-a" Bond

dc.contributor.author Akhremitchev, Boris B
dc.date.accessioned 2011-06-21T17:26:44Z
dc.date.available 2011-06-21T17:26:44Z
dc.date.issued 2010
dc.identifier.citation Averett,Laurel E.;Akhremitchev,Boris B.;Schoenfisch,Mark H.;Gorkun,Oleg V.. 2010. Calcium Dependence of Fibrin Nanomechanics: The gamma 1 Calcium Mediates the Unfolding of Fibrinogen Induced by Force Applied to the "A-a" Bond. Langmuir 26(18): 14716-14722.
dc.identifier.issn 0743-7463
dc.identifier.uri https://hdl.handle.net/10161/4081
dc.description.abstract The interactions between the constituent monomers of fibrin, the polymerized protein network that provides the structural stability of blood clots, ale frequently under stress because of the dynamic nature of blood flow Herein, the calcium dependence of the structural unfolding linked to the forced dissociation of the "A-a" knob-hole bond between fibrin monomers is reported The presence of calcium was shown to influence the incidence of the last event in the unfolding pattern characteristic of "A-a" rupture This effect, attributed to the function of the gamma 1 calcium-binding site, was found to be reversible and specific Our results indicate that binding of calcium at the gamma 1 site has no effect on the strength of the knob-hole bond prior to unfolding of the hole-containing gamma module Rather, calcium bound at the gamma 1 site makes the structure of the hole mole resilient to such forced unfolding, leading to survival of the "A-a" knob-hole bond during large: extensions of the fibrinogen molecule but at the cost of rupture of the bond at lower forces
dc.language.iso en_US
dc.publisher AMER CHEMICAL SOC
dc.relation.isversionof 10.1021/la.1017664
dc.subject b-b interactions
dc.subject crystal-structure
dc.subject single-molecule
dc.subject vlissingen/frankfurt iv
dc.subject platelet-aggregation
dc.subject polymerization site
dc.subject n-terminus
dc.subject binding
dc.subject chain
dc.subject fragment
dc.subject chemistry, multidisciplinary
dc.subject chemistry, physical
dc.subject materials science, multidisciplinary
dc.title Calcium Dependence of Fibrin Nanomechanics: The gamma 1 Calcium Mediates the Unfolding of Fibrinogen Induced by Force Applied to the "A-a" Bond
dc.title.alternative
dc.type Other article
dc.description.version Version of Record
duke.date.pubdate 2010-9-21
duke.description.issue 18
duke.description.volume 26
dc.relation.journal Langmuir
pubs.begin-page 14716
pubs.end-page 14722


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