dc.contributor.author |
Akhremitchev, Boris B |
|
dc.date.accessioned |
2011-06-21T17:26:44Z |
|
dc.date.available |
2011-06-21T17:26:44Z |
|
dc.date.issued |
2010 |
|
dc.identifier.citation |
Averett,Laurel E.;Akhremitchev,Boris B.;Schoenfisch,Mark H.;Gorkun,Oleg V.. 2010.
Calcium Dependence of Fibrin Nanomechanics: The gamma 1 Calcium Mediates the Unfolding
of Fibrinogen Induced by Force Applied to the "A-a" Bond. Langmuir 26(18): 14716-14722.
|
|
dc.identifier.issn |
0743-7463 |
|
dc.identifier.uri |
https://hdl.handle.net/10161/4081 |
|
dc.description.abstract |
The interactions between the constituent monomers of fibrin, the polymerized protein
network that provides the structural stability of blood clots, ale frequently under
stress because of the dynamic nature of blood flow Herein, the calcium dependence
of the structural unfolding linked to the forced dissociation of the "A-a" knob-hole
bond between fibrin monomers is reported The presence of calcium was shown to influence
the incidence of the last event in the unfolding pattern characteristic of "A-a" rupture
This effect, attributed to the function of the gamma 1 calcium-binding site, was found
to be reversible and specific Our results indicate that binding of calcium at the
gamma 1 site has no effect on the strength of the knob-hole bond prior to unfolding
of the hole-containing gamma module Rather, calcium bound at the gamma 1 site makes
the structure of the hole mole resilient to such forced unfolding, leading to survival
of the "A-a" knob-hole bond during large: extensions of the fibrinogen molecule but
at the cost of rupture of the bond at lower forces
|
|
dc.language.iso |
en_US |
|
dc.publisher |
AMER CHEMICAL SOC |
|
dc.relation.isversionof |
10.1021/la.1017664 |
|
dc.subject |
b-b interactions |
|
dc.subject |
crystal-structure |
|
dc.subject |
single-molecule |
|
dc.subject |
vlissingen/frankfurt iv |
|
dc.subject |
platelet-aggregation |
|
dc.subject |
polymerization site |
|
dc.subject |
n-terminus |
|
dc.subject |
binding |
|
dc.subject |
chain |
|
dc.subject |
fragment |
|
dc.subject |
chemistry, multidisciplinary |
|
dc.subject |
chemistry, physical |
|
dc.subject |
materials science, multidisciplinary |
|
dc.title |
Calcium Dependence of Fibrin Nanomechanics: The gamma 1 Calcium Mediates the Unfolding
of Fibrinogen Induced by Force Applied to the "A-a" Bond
|
|
dc.title.alternative |
|
|
dc.type |
Other article |
|
dc.description.version |
Version of Record |
|
duke.date.pubdate |
2010-9-21 |
|
duke.description.issue |
18 |
|
duke.description.volume |
26 |
|
dc.relation.journal |
Langmuir |
|
pubs.begin-page |
14716 |
|
pubs.end-page |
14722 |
|