Show simple item record Kersey, FR Zhang, G Palmer, GM Dewhirst, MW Fraser, CL
dc.coverage.spatial United States 2011-06-21T17:27:06Z 2010-09-28
dc.identifier.citation ACS Nano, 2010, 4 (9), pp. 4989 - 4996
dc.description.abstract Responsive biomaterials play important roles in imaging, diagnostics, and therapeutics. Polymeric nanoparticles (NPs) containing hydrophobic and hydrophilic segments are one class of biomaterial utilized for these purposes. The incorporation of luminescent molecules into NPs adds optical imaging and sensing capability to these vectors. Here we report on the synthesis of dual-emissive, pegylated NPs with "stealth"-like properties, delivered intravenously (IV), for the study of tumor accumulation. The NPs were created by means of stereocomplexation using a methoxy-terminated polyethylene glycol and poly(D-lactide) (mPEG-PDLA) block copolymer combined with iodide-substituted difluoroboron dibenzoylmethane-poly(L-lactide) (BF2dbm(I)PLLA). Boron nanoparticles (BNPs) were fabricated in two different solvent compositions to study the effects on BNP size distribution. The physical and photoluminescent properties of the BNPs were studied in vitro over time to determine stability. Finally, preliminary in vivo results show that stereocomplexed BNPs injected IV are taken up by tumors, an important prerequisite to their use as hypoxia imaging agents in preclinical studies.
dc.format.extent 4989 - 4996
dc.language eng
dc.language.iso en_US en_US
dc.relation.ispartof ACS Nano
dc.relation.isversionof 10.1021/nn901873t
dc.subject Absorption
dc.subject Animals
dc.subject Biological Transport
dc.subject Boron
dc.subject Coloring Agents
dc.subject Lactic Acid
dc.subject Mammary Neoplasms, Experimental
dc.subject Mice
dc.subject Molecular Imaging
dc.subject Nanomedicine
dc.subject Nanoparticles
dc.subject Polyesters
dc.subject Polyethylene Glycols
dc.subject Polymers
dc.subject Solvents
dc.subject Spectrum Analysis
dc.subject Stereoisomerism
dc.title Stereocomplexed poly(lactic acid)-poly(ethylene glycol) nanoparticles with dual-emissive boron dyes for tumor accumulation.
dc.title.alternative en_US
dc.type Journal Article
dc.description.version Version of Record en_US 2010-9-0 en_US
duke.description.endpage 4996 en_US
duke.description.issue 9 en_US
duke.description.startpage 4989 en_US
duke.description.volume 4 en_US
dc.relation.journal Acs Nano en_US
pubs.issue 9
pubs.organisational-group /Duke
pubs.organisational-group /Duke/Pratt School of Engineering
pubs.organisational-group /Duke/Pratt School of Engineering/Biomedical Engineering
pubs.organisational-group /Duke/School of Medicine
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments/Pathology
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments/Radiation Oncology
pubs.organisational-group /Duke/School of Medicine/Institutes and Centers
pubs.organisational-group /Duke/School of Medicine/Institutes and Centers/Duke Cancer Institute
pubs.organisational-group /Duke/Trinity College of Arts & Sciences
pubs.organisational-group /Duke/Trinity College of Arts & Sciences/Chemistry
pubs.publication-status Published
pubs.volume 4
dc.identifier.eissn 1936-086X

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