Total synthesis of cyanolide A and confirmation of its absolute configuration.
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The tandem allylic oxidation/oxa-Michael reaction promoted by the gem-disubstituent effect and the 2-methyl-6-nitrobenzoic anhydride (MNBA)-mediated dimerization were explored for the efficient and facile synthesis of cyanolide A.
Published Version (Please cite this version)10.1021/ol101022z
Publication InfoKim, Hyoungsu; & Hong, Jiyong (2010). Total synthesis of cyanolide A and confirmation of its absolute configuration. Org Lett, 12(12). pp. 2880-2883. 10.1021/ol101022z. Retrieved from https://hdl.handle.net/10161/4106.
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Professor of Chemistry
Research in the Hong group focuses on using chemical tools, in particular small molecules, to understand the signaling pathways in biology. We synthesize biologically interesting natural products and screen small molecule libraries to identify modulators of biological processes. Then, we explore their modes of action in order to investigate intracellular signaling pathways and identify novel targets for drug design. In addition, we design and develop unique and efficient synthetic strategies tha