Total synthesis of cyanolide A and confirmation of its absolute configuration.
Abstract
The tandem allylic oxidation/oxa-Michael reaction promoted by the gem-disubstituent
effect and the 2-methyl-6-nitrobenzoic anhydride (MNBA)-mediated dimerization were
explored for the efficient and facile synthesis of cyanolide A.
Type
Journal articleSubject
AnhydridesAnimals
Glycosylation
Macrolides
Molecular Structure
Nitrobenzoates
Oxidation-Reduction
Schistosoma
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https://hdl.handle.net/10161/4106Published Version (Please cite this version)
10.1021/ol101022zPublication Info
(2010). Total synthesis of cyanolide A and confirmation of its absolute configuration. Org Lett, 12(12). pp. 2880-2883. 10.1021/ol101022z. Retrieved from https://hdl.handle.net/10161/4106.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
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Show full item recordScholars@Duke
Jiyong Hong
Professor of Chemistry
Research in the Hong group focuses on using chemical tools, in particular small molecules,
to understand the signaling pathways in biology. We synthesize biologically interesting
natural products and screen small molecule libraries to identify modulators of biological
processes. Then, we explore their modes of action in order to investigate intracellular
signaling pathways and identify novel targets for drug design. In addition, we design
and develop unique and efficient synthetic strategies tha
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