Reductive ligation mediated one-step disulfide formation of S-nitrosothiols.
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A one-step reductive ligation mediated disulfide formation of S-nitrosothiols was developed. This reaction involves the reaction of the S-nitroso group with phosphine-thioesters to form sulfenamide and thiolate intermediates, which then undergo a fast intermolecular disulfide formation to form stable conjugates. This reaction can be used to design new biosensors of S-nitrosated proteins.
Published Version (Please cite this version)10.1021/ol101863s
Publication InfoZhang, Jiming; Li, Sheng; Zhang, Dehui; Wang, Hua; Whorton, A Richard; & Xian, Ming (2010). Reductive ligation mediated one-step disulfide formation of S-nitrosothiols. Org Lett, 12(18). pp. 4208-4211. 10.1021/ol101863s. Retrieved from https://hdl.handle.net/10161/4108.
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Associate Professor of Pharmacology & Cancer Biology
Our group is interested in mechanisms for physiological responses to nitric oxide (NO). Although NO may act directly on cells to elicit responses, other important effects of NO are mediated by S-nitrosothiols derived by the reaction of NO derivatives and cysteine thiols. Recently we have found that the amino acid transporters, LAT1 and LAT2, transport S-nitroso-L-cysteine into cells. This mechanism provides a specific and selective pathway for movement NO-bioactivity into cells. Once inside
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