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Reductive ligation mediated one-step disulfide formation of S-nitrosothiols.

dc.contributor.author Zhang, Jiming
dc.contributor.author Li, Sheng
dc.contributor.author Zhang, Dehui
dc.contributor.author Wang, Hua
dc.contributor.author Whorton, A Richard
dc.contributor.author Xian, Ming
dc.coverage.spatial United States
dc.date.accessioned 2011-06-21T17:27:11Z
dc.date.issued 2010-09-17
dc.identifier http://www.ncbi.nlm.nih.gov/pubmed/20731371
dc.identifier.uri https://hdl.handle.net/10161/4108
dc.description.abstract A one-step reductive ligation mediated disulfide formation of S-nitrosothiols was developed. This reaction involves the reaction of the S-nitroso group with phosphine-thioesters to form sulfenamide and thiolate intermediates, which then undergo a fast intermolecular disulfide formation to form stable conjugates. This reaction can be used to design new biosensors of S-nitrosated proteins.
dc.language eng
dc.language.iso en_US
dc.publisher American Chemical Society (ACS)
dc.relation.ispartof Org Lett
dc.relation.isversionof 10.1021/ol101863s
dc.subject Disulfides
dc.subject Molecular Structure
dc.subject Oxidation-Reduction
dc.subject Phosphines
dc.subject S-Nitrosothiols
dc.title Reductive ligation mediated one-step disulfide formation of S-nitrosothiols.
dc.title.alternative
dc.type Journal article
duke.contributor.id Whorton, A Richard|0115028
dc.description.version Version of Record
duke.date.pubdate 2010-9-17
duke.description.issue 18
duke.description.volume 12
dc.relation.journal Organic letters
pubs.author-url http://www.ncbi.nlm.nih.gov/pubmed/20731371
pubs.begin-page 4208
pubs.end-page 4211
pubs.issue 18
pubs.organisational-group Duke
pubs.organisational-group Faculty
pubs.publication-status Published
pubs.volume 12
dc.identifier.eissn 1523-7052


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