Burkholdines 1097 and 1229, Potent Antifungal Peptides from Burkholderia ambifaria 2.2N
Abstract
Potent antifungal cyclic lipopeptides, burkholdines (Bk), were isolated from a culture
of Burkholderia ambifaria 2.2N. Bk-1229 (1) and Bk-1097 (2) are octapeptides comprised
of nonproteinogenic amino acids, including beta-hydroxytyrosine, beta-hydroxyasparagine,
and a new fatty acyl amino acid. 1 and 2 are fungicidal against a panel of fungi with
potencies 2-60-fold better than amphotericin B control.
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https://hdl.handle.net/10161/4111Published Version (Please cite this version)
10.1021/ol9029269Citation
Tawfik,Kamilia A.;Jeffs,Peter;Bray,Brian;Dubay,George;Falkinham,Joseph O.,,III;Mesbah,Mostafa;Youssef,Diaa;Khalifa,Sherief;Schmidt,Eric
W.. 2010. Burkholdines 1097 and 1229, Potent Antifungal Peptides from Burkholderia
ambifaria 2.2N. Organic letters 12(4): 664-666.
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