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Minding metals: tailoring multifunctional chelating agents for neurodegenerative disease.

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Date
2010-03-07
Authors
Perez, Lissette R
Franz, Katherine J
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Abstract
Neurodegenerative diseases like Alzheimer's and Parkinson's disease are associated with elevated levels of iron, copper, and zinc and consequentially high levels of oxidative stress. Given the multifactorial nature of these diseases, it is becoming evident that the next generation of therapies must have multiple functions to combat multiple mechanisms of disease progression. Metal-chelating agents provide one such function as an intervention for ameliorating metal-associated damage in degenerative diseases. Targeting chelators to adjust localized metal imbalances in the brain, however, presents significant challenges. In this perspective, we focus on some noteworthy advances in the area of multifunctional metal chelators as potential therapeutic agents for neurodegenerative diseases. In addition to metal chelating ability, these agents also contain features designed to improve their uptake across the blood-brain barrier, increase their selectivity for metals in damage-prone environments, increase antioxidant capabilities, lower Abeta peptide aggregation, or inhibit disease-associated enzymes such as monoamine oxidase and acetylcholinesterase.
Type
Journal article
Subject
Chelating Agents
Humans
Metals
Neurodegenerative Diseases
Permalink
https://hdl.handle.net/10161/4119
Published Version (Please cite this version)
10.1039/b919237a
Publication Info
Perez, Lissette R; & Franz, Katherine J (2010). Minding metals: tailoring multifunctional chelating agents for neurodegenerative disease. Dalton Trans, 39(9). pp. 2177-2187. 10.1039/b919237a. Retrieved from https://hdl.handle.net/10161/4119.
This is constructed from limited available data and may be imprecise. To cite this article, please review & use the official citation provided by the journal.
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Scholars@Duke

Franz

Katherine J. Franz

Chair of the Department of Chemistry
Research in the Franz group is involved in elucidating the structural and functional consequences of metal ion coordination in biological systems. We are particularly interested in understanding the coordination chemistry utilized by biology to manage essential yet toxic species like copper and iron. Understanding these principles further guides our development of new chemical tools to manipulate biological metal ion location, speciation, and reactivity for potential therapeutic benefit. We use
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