Show simple item record

Lessons Learned from the Anaerobe Survey: Historical Perspective and Review of the Most Recent Data (2005-2007)

dc.contributor.author Snydman, David R
dc.contributor.author Jacobus, Nilda V
dc.contributor.author McDermott, Laura A
dc.contributor.author Golan, Yoav
dc.contributor.author Hecht, David W
dc.contributor.author Goldstein, Ellie JC
dc.contributor.author Harrell, Lizzie
dc.contributor.author Jenkins, Stephen
dc.contributor.author Newton, Duane
dc.contributor.author Pierson, Carl
dc.contributor.author Rihs, John D
dc.contributor.author Yu, Victor L
dc.contributor.author Venezia, Richard
dc.contributor.author Finegold, Sydney M
dc.contributor.author Rosenblatt, Jon E
dc.contributor.author Gorbach, Sherwood L
dc.date.accessioned 2011-06-21T17:27:18Z
dc.date.available 2011-06-21T17:27:18Z
dc.date.issued 2010
dc.identifier.citation Snydman,David R.;Jacobus,Nilda V.;McDermott,Laura A.;Golan,Yoav;Hecht,David W.;Goldstein,Ellie J. C.;Harrell,Lizzie;Jenkins,Stephen;Newton,Duane;Pierson,Carl;Rihs,John D.;Yu,Victor L.;Venezia,Richard;Finegold,Sydney M.;Rosenblatt,Jon E.;Gorbach,Sherwood L.. 2010. Lessons Learned from the Anaerobe Survey: Historical Perspective and Review of the Most Recent Data (2005-2007). Clinical Infectious Diseases 50( ): S26-S33.
dc.identifier.issn 1058-4838
dc.identifier.uri https://hdl.handle.net/10161/4135
dc.description.abstract Background. The rationale and lessons learned through the evolution of the National Survey for the Susceptibility of Bacteroides fragilis Group from its initiation in 1981 through 2007 are reviewed here. The survey was conceived in 1980 to track emerging antimicrobial resistance in Bacteroides species. Methods. Data from the last 11 years of the survey (1997-2007), including 6574 isolates from 13 medical centers, were analyzed for in vitro antimicrobial resistance to both frequently used and newly developed anti-anaerobic agents. The minimum inhibitory concentrations of the antibiotics were determined using agar dilution in accordance with Clinical and Laboratory Standards Institute recommendations. Results. The analyses revealed that the carbapenems (imipenem, meropenem, ertapenem, and doripenem) and piperacillin-tazobactam were the most active agents against these pathogens, with resistance rates of 0.9%-2.3%. In the most recent 3 years of the survey (2005-2007), resistance to some agents was shown to depend on the species, such as ampicillin-sulbactam against Bacteroides distasonis (20.6%) and tigecycline against Bacteroides uniformis and Bacteroides eggerthii (similar to 7%). Very high resistance rates (>50%) were noted for moxifloxacin and trovafloxacin, particularly against Bacteroides vulgatus. During that period of study, non-B. fragilis Bacteroides species had >40% resistance to clindamycin. Metronidazole-resistant Bacteroides strains were also first reported during that period. Conclusions. In summary, resistance to antibiotics was greater among non-B. fragilis Bacteroides species than among B. fragilis and was especially greater among species with a low frequency of isolation, such as Bacteroides caccae and B. uniformis. The emergence of resistance among the non-B. fragilis Bacteroides species underscores the need for speciation of B. fragilis group isolates and for clinicians to be aware of associations between species and drug resistance.
dc.language.iso en_US
dc.publisher Oxford University Press (OUP)
dc.relation.isversionof 10.1086/647940
dc.subject bacteroides-fragilis group
dc.subject antimicrobial susceptibility patterns
dc.subject in-vitro activities
dc.subject united-states
dc.subject national-survey
dc.subject resistance
dc.subject trends
dc.subject multicenter
dc.subject bacteria
dc.subject immunology
dc.subject infectious diseases
dc.subject microbiology
dc.title Lessons Learned from the Anaerobe Survey: Historical Perspective and Review of the Most Recent Data (2005-2007)
dc.title.alternative
dc.type Other article
duke.contributor.id Harrell, Lizzie|0102175
dc.description.version Version of Record
duke.date.pubdate 2010-1-1
duke.description.issue
duke.description.volume 50
dc.relation.journal Clinical Infectious Diseases
pubs.begin-page S26
pubs.end-page S33


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record