Global Trends in Typhoid and Paratyphoid Fever
Abstract
Typhoid and paratyphoid fever continue to be important causes of illness and death,
particularly among children and adolescents in south-central and Southeast Asia, where
enteric fever is associated with poor sanitation and unsafe food and water. High-quality
incidence data from Asia are underpinning efforts to expand access to typhoid vaccines.
Efforts are underway to develop vaccines that are immunogenic in infants after a single
dose and that can be produced locally in countries of endemicity. The growing importance
of Salmonella enterica serotype Paratyphi A in Asia is concerning. Antimicrobial resistance
has sequentially emerged to traditional first-line drugs, fluoroquinolones, and third-generation
cephalosporins, posing patient treatment challenges. Azithromycin has proven to be
an effective alternative for treatment of uncomplicated typhoid fever. The availability
of full genome sequences for S. enterica serotype Typhi and S. enterica serotype Paratyphi
A confirms their place as monomorphic, human-adapted pathogens vulnerable to control
measures if international efforts can be redoubled.
Type
Other articleSubject
enterica serotype typhiresistant salmonella-typhi
antimicrobial
resistance
multidrug-resistant
united-states
developing-countries
serovars paratyphi
asian countries
vaccine
surveillance
immunology
infectious diseases
microbiology
Permalink
https://hdl.handle.net/10161/4136Published Version (Please cite this version)
10.1086/649541Citation
Crump,John A.;Mintz,Eric D.. 2010. Global Trends in Typhoid and Paratyphoid Fever.
Clinical Infectious Diseases 50(2): 241-246.
Collections
More Info
Show full item record
Articles written by Duke faculty are made available through the campus open access policy. For more information see: Duke Open Access Policy
Rights for Collection: Scholarly Articles
Works are deposited here by their authors, and represent their research and opinions, not that of Duke University. Some materials and descriptions may include offensive content. More info