Show simple item record Crump, John en_US 2011-06-21T17:27:18Z 2011-06-21T17:27:18Z 2010 en_US
dc.identifier.citation Crump,John A.;Mintz,Eric D.. 2010. Global Trends in Typhoid and Paratyphoid Fever. Clinical Infectious Diseases 50(2): 241-246. en_US
dc.identifier.issn 1058-4838 en_US
dc.description.abstract Typhoid and paratyphoid fever continue to be important causes of illness and death, particularly among children and adolescents in south-central and Southeast Asia, where enteric fever is associated with poor sanitation and unsafe food and water. High-quality incidence data from Asia are underpinning efforts to expand access to typhoid vaccines. Efforts are underway to develop vaccines that are immunogenic in infants after a single dose and that can be produced locally in countries of endemicity. The growing importance of Salmonella enterica serotype Paratyphi A in Asia is concerning. Antimicrobial resistance has sequentially emerged to traditional first-line drugs, fluoroquinolones, and third-generation cephalosporins, posing patient treatment challenges. Azithromycin has proven to be an effective alternative for treatment of uncomplicated typhoid fever. The availability of full genome sequences for S. enterica serotype Typhi and S. enterica serotype Paratyphi A confirms their place as monomorphic, human-adapted pathogens vulnerable to control measures if international efforts can be redoubled. en_US
dc.language.iso en_US en_US
dc.publisher UNIV CHICAGO PRESS en_US
dc.relation.isversionof doi:10.1086/649541 en_US
dc.subject enterica serotype typhi en_US
dc.subject resistant salmonella-typhi en_US
dc.subject antimicrobial en_US
dc.subject resistance en_US
dc.subject multidrug-resistant en_US
dc.subject united-states en_US
dc.subject developing-countries en_US
dc.subject serovars paratyphi en_US
dc.subject asian countries en_US
dc.subject vaccine en_US
dc.subject surveillance en_US
dc.subject immunology en_US
dc.subject infectious diseases en_US
dc.subject microbiology en_US
dc.title Global Trends in Typhoid and Paratyphoid Fever en_US
dc.title.alternative en_US
dc.description.version Version of Record en_US 2010-1-15 en_US
duke.description.endpage 246 en_US
duke.description.issue 2 en_US
duke.description.startpage 241 en_US
duke.description.volume 50 en_US
dc.relation.journal Clinical Infectious Diseases en_US

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