Show simple item record Pelak, K Goldstein, DB Walley, NM Fellay, J Ge, D Shianna, KV Gumbs, C Gao, X Maia, JM Cronin, KD Hussain, SK Carrington, M Michael, NL Weintrob, AC Infectious Disease Clinical Research Program HIV Working Group National Institute of Allergy and Infectious Diseases Center for HIV/AIDS Vaccine Immunology (CHAVI)
dc.coverage.spatial United States 2011-06-21T17:27:21Z 2010-04-15
dc.identifier.citation J Infect Dis, 2010, 201 (8), pp. 1141 - 1149
dc.description.abstract We performed a whole-genome association study of human immunodeficiency virus type 1 (HIV-1) set point among a cohort of African Americans (n = 515), and an intronic single-nucleotide polymorphism (SNP) in the HLA-B gene showed one of the strongest associations. We use a subset of patients to demonstrate that this SNP reflects the effect of the HLA-B*5703 allele, which shows a genome-wide statistically significant association with viral load set point (P = 5.6 x 10(-10)). These analyses therefore confirm a member of the HLA-B*57 group of alleles as the most important common variant that influences viral load variation in African Americans, which is consistent with what has been observed for individuals of European ancestry, among whom the most important common variant is HLA-B*5701.
dc.format.extent 1141 - 1149
dc.language eng
dc.language.iso en_US en_US
dc.relation.ispartof J Infect Dis
dc.relation.isversionof 10.1086/651382
dc.subject Adolescent
dc.subject Adult
dc.subject African Americans
dc.subject DNA-Binding Proteins
dc.subject Disease Progression
dc.subject Genome-Wide Association Study
dc.subject Genotype
dc.subject HIV Infections
dc.subject HIV-1
dc.subject HLA-B Antigens
dc.subject HLA-C Antigens
dc.subject Humans
dc.subject Male
dc.subject Middle Aged
dc.subject Phenotype
dc.subject Polymorphism, Single Nucleotide
dc.subject Viral Load
dc.subject Young Adult
dc.title Host determinants of HIV-1 control in African Americans.
dc.title.alternative en_US
dc.type Journal Article
dc.description.version Version of Record en_US 2010-4-15 en_US
duke.description.endpage 1149 en_US
duke.description.issue 8 en_US
duke.description.startpage 1141 en_US
duke.description.volume 201 en_US
dc.relation.journal Journal of Infectious Diseases en_US
pubs.issue 8
pubs.organisational-group /Duke
pubs.organisational-group /Duke/Institutes and Provost's Academic Units
pubs.organisational-group /Duke/Institutes and Provost's Academic Units/University Institutes and Centers
pubs.organisational-group /Duke/Institutes and Provost's Academic Units/University Institutes and Centers/Duke Institute for Brain Sciences
pubs.organisational-group /Duke/School of Medicine
pubs.organisational-group /Duke/School of Medicine/Basic Science Departments
pubs.organisational-group /Duke/School of Medicine/Basic Science Departments/Molecular Genetics and Microbiology
pubs.organisational-group /Duke/School of Medicine/Institutes and Centers
pubs.organisational-group /Duke/School of Medicine/Institutes and Centers/Duke Center for Human Genome Variation
pubs.organisational-group /Duke/School of Medicine/Institutes and Centers/Duke Clinical Research Institute
pubs.publication-status Published
pubs.volume 201
dc.identifier.eissn 1537-6613

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