Show simple item record Anderson, DJ Arduino, JM Reed, SD Sexton, DJ Kaye, KS Grussemeyer, CA Peter, SA Hardy, C Choi, YI Friedman, JY Fowler, VG
dc.coverage.spatial United States 2011-06-21T17:27:21Z 2010-07
dc.identifier.citation Infect Control Hosp Epidemiol, 2010, 31 (7), pp. 701 - 709
dc.description.abstract OBJECTIVE: To determine the epidemiological characteristics of postoperative invasive Staphylococcus aureus infection following 4 types of major surgical Retrospective cohort study. SETTING: Eleven hospitals (9 community hospitals and 2 tertiary care hospitals) in North Carolina and Virginia. PATIENTS: Adults undergoing orthopedic, neurosurgical, cardiothoracic, and plastic surgical procedures. METHODS: We used previously validated, prospectively collected surgical surveillance data for surgical site infection and microbiological data for bloodstream infection. The study period was 2003 through 2006. We defined invasive S. aureus infection as either nonsuperficial incisional surgical site infection or bloodstream infection. Nonparametric bootstrapping was used to generate 95% confidence intervals (CIs). P values were generated using the Pearson chi2 test, Student t test, or Wilcoxon rank-sum test, as appropriate. RESULTS: In total, 81,267 patients underwent 96,455 procedures during the study period. The overall incidence of invasive S. aureus infection was 0.47 infections per 100 procedures (95% CI, 0.43-0.52); 227 (51%) of 446 infections were due to methicillin-resistant S.aureus. Invasive S. aureus infection was more common after cardiothoracic procedures (incidence, 0.79 infections per 100 procedures [95%CI, 0.62-0.97]) than after orthopedic procedures (0.37 infections per 100 procedures [95% CI, 0.32-0.42]), neurosurgical procedures (0.62 infections per 100 procedures [95% CI, 0.53-0.72]), or plastic surgical procedures (0.32 infections per 100 procedures [95% CI, 0.17-0.47]) (P < .001). Similarly, S. aureus bloodstream infection was most common after cardiothoracic procedures (incidence, 0.57 infections per 100 procedures [95% CI, 0.43-0.72]; P < .001, compared with other procedure types), comprising almost three-quarters of the invasive S. aureus infections after these procedures. The highest rate of surgical site infection was observed after neurosurgical procedures (incidence, 0.50 infections per 100 procedures [95% CI, 0.42-0.59]; P < .001, compared with other procedure types), comprising 80% of invasive S.aureus infections after these procedures. CONCLUSION: The frequency and type of postoperative invasive S. aureus infection varied significantly across procedure types. The highest risk procedures, such as cardiothoracic procedures, should be targeted for ongoing preventative interventions.
dc.format.extent 701 - 709
dc.language eng
dc.language.iso en_US en_US
dc.relation.ispartof Infect Control Hosp Epidemiol
dc.relation.isversionof 10.1086/653205
dc.subject Adolescent
dc.subject Adult
dc.subject Aged
dc.subject Aged, 80 and over
dc.subject Bacteremia
dc.subject Cardiac Surgical Procedures
dc.subject Cohort Studies
dc.subject Cross Infection
dc.subject Female
dc.subject Hospitals
dc.subject Humans
dc.subject Incidence
dc.subject Male
dc.subject Methicillin-Resistant Staphylococcus aureus
dc.subject Middle Aged
dc.subject North Carolina
dc.subject Orthopedic Procedures
dc.subject Postoperative Complications
dc.subject Retrospective Studies
dc.subject Staphylococcal Infections
dc.subject Staphylococcus aureus
dc.subject Surgical Procedures, Operative
dc.subject Surgical Wound Infection
dc.subject Thoracic Surgical Procedures
dc.subject Virginia
dc.subject Young Adult
dc.title Variation in the type and frequency of postoperative invasive Staphylococcus aureus infections according to type of surgical procedure.
dc.title.alternative en_US
dc.type Journal Article
dc.description.version Version of Record en_US 2010-7-0 en_US
duke.description.endpage 709 en_US
duke.description.issue 7 en_US
duke.description.startpage 701 en_US
duke.description.volume 31 en_US
dc.relation.journal Infection Control and Hospital Epidemiology en_US
pubs.issue 7
pubs.organisational-group /Duke
pubs.organisational-group /Duke/School of Medicine
pubs.organisational-group /Duke/School of Medicine/Basic Science Departments
pubs.organisational-group /Duke/School of Medicine/Basic Science Departments/Molecular Genetics and Microbiology
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments/Medicine
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments/Medicine/Medicine, General Internal Medicine
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments/Medicine/Medicine, Infectious Diseases
pubs.organisational-group /Duke/School of Medicine/Institutes and Centers
pubs.organisational-group /Duke/School of Medicine/Institutes and Centers/Duke Cancer Institute
pubs.organisational-group /Duke/School of Medicine/Institutes and Centers/Duke Clinical Research Institute
pubs.publication-status Published
pubs.volume 31
dc.identifier.eissn 1559-6834

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