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The humoral response to HIV-1: new insights, renewed focus.

dc.contributor.author Alter, Galit
dc.contributor.author Moody, M Anthony
dc.coverage.spatial United States
dc.date.accessioned 2011-06-21T17:27:22Z
dc.date.issued 2010-10-15
dc.identifier http://www.ncbi.nlm.nih.gov/pubmed/20846039
dc.identifier.uri https://hdl.handle.net/10161/4156
dc.description.abstract During the past 2 decades, significant advances in our understanding of the humoral immune response to human immunodeficiency virus type 1 (HIV-1) infection have been made, yet a tremendous amount of work lies ahead. Despite these advances, strategies to reliably induce antibodies that can control HIV-1 infection are still critically needed. However, recent advances in our understanding of the kinetics, specificity, and function of early humoral responses offer alternative new approaches to attain this goal. These results, along with the new broadly neutralizing antibody specificities, the role for other antibody functions, the increased understanding of HIV-1-induced changes to B cell biology, and results from the RV144 "Thai" trial showing potential modest sterilizing protection by nonneutralizing antibody responses, have renewed focus on the humoral system. In this review, recent advances in our understanding of the earliest humoral responses are discussed, highlighting presentations from the meeting on the Biology of Acute HIV Infection.
dc.language eng
dc.language.iso en_US
dc.publisher Oxford University Press (OUP)
dc.relation.ispartof J Infect Dis
dc.relation.isversionof 10.1086/655654
dc.subject Antibodies, Neutralizing
dc.subject HIV Antibodies
dc.subject HIV Infections
dc.subject HIV-1
dc.subject Humans
dc.title The humoral response to HIV-1: new insights, renewed focus.
dc.title.alternative
dc.type Journal article
duke.contributor.id Moody, M Anthony|0028821
dc.description.version Version of Record
duke.date.pubdate 2010-10-15
duke.description.issue
duke.description.volume 202
dc.relation.journal Journal of Infectious Diseases
pubs.author-url http://www.ncbi.nlm.nih.gov/pubmed/20846039
pubs.begin-page S315
pubs.end-page S322
pubs.organisational-group Basic Science Departments
pubs.organisational-group Clinical Science Departments
pubs.organisational-group Duke
pubs.organisational-group Duke Human Vaccine Institute
pubs.organisational-group Immunology
pubs.organisational-group Institutes and Centers
pubs.organisational-group Pediatrics
pubs.organisational-group Pediatrics, Infectious Diseases
pubs.organisational-group School of Medicine
pubs.publication-status Published
pubs.volume 202 Suppl 2
dc.identifier.eissn 1537-6613
duke.contributor.orcid Moody, M Anthony|0000-0002-3890-5855


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