dc.contributor.author |
Alter, Galit |
|
dc.contributor.author |
Moody, M Anthony |
|
dc.coverage.spatial |
United States |
|
dc.date.accessioned |
2011-06-21T17:27:22Z |
|
dc.date.issued |
2010-10-15 |
|
dc.identifier |
http://www.ncbi.nlm.nih.gov/pubmed/20846039 |
|
dc.identifier.uri |
https://hdl.handle.net/10161/4156 |
|
dc.description.abstract |
During the past 2 decades, significant advances in our understanding of the humoral
immune response to human immunodeficiency virus type 1 (HIV-1) infection have been
made, yet a tremendous amount of work lies ahead. Despite these advances, strategies
to reliably induce antibodies that can control HIV-1 infection are still critically
needed. However, recent advances in our understanding of the kinetics, specificity,
and function of early humoral responses offer alternative new approaches to attain
this goal. These results, along with the new broadly neutralizing antibody specificities,
the role for other antibody functions, the increased understanding of HIV-1-induced
changes to B cell biology, and results from the RV144 "Thai" trial showing potential
modest sterilizing protection by nonneutralizing antibody responses, have renewed
focus on the humoral system. In this review, recent advances in our understanding
of the earliest humoral responses are discussed, highlighting presentations from the
meeting on the Biology of Acute HIV Infection.
|
|
dc.language |
eng |
|
dc.language.iso |
en_US |
|
dc.publisher |
Oxford University Press (OUP) |
|
dc.relation.ispartof |
J Infect Dis |
|
dc.relation.isversionof |
10.1086/655654 |
|
dc.subject |
Antibodies, Neutralizing |
|
dc.subject |
HIV Antibodies |
|
dc.subject |
HIV Infections |
|
dc.subject |
HIV-1 |
|
dc.subject |
Humans |
|
dc.title |
The humoral response to HIV-1: new insights, renewed focus. |
|
dc.title.alternative |
|
|
dc.type |
Journal article |
|
duke.contributor.id |
Moody, M Anthony|0028821 |
|
dc.description.version |
Version of Record |
|
duke.date.pubdate |
2010-10-15 |
|
duke.description.issue |
|
|
duke.description.volume |
202 |
|
dc.relation.journal |
Journal of Infectious Diseases |
|
pubs.author-url |
http://www.ncbi.nlm.nih.gov/pubmed/20846039 |
|
pubs.begin-page |
S315 |
|
pubs.end-page |
S322 |
|
pubs.organisational-group |
Basic Science Departments |
|
pubs.organisational-group |
Clinical Science Departments |
|
pubs.organisational-group |
Duke |
|
pubs.organisational-group |
Duke Human Vaccine Institute |
|
pubs.organisational-group |
Immunology |
|
pubs.organisational-group |
Institutes and Centers |
|
pubs.organisational-group |
Pediatrics |
|
pubs.organisational-group |
Pediatrics, Infectious Diseases |
|
pubs.organisational-group |
School of Medicine |
|
pubs.publication-status |
Published |
|
pubs.volume |
202 Suppl 2 |
|
dc.identifier.eissn |
1537-6613 |
|
duke.contributor.orcid |
Moody, M Anthony|0000-0002-3890-5855 |
|