Show simple item record Lederman, MM Alter, G Daskalakis, DC Rodriguez, B Sieg, SF Hardy, G Cho, M Anthony, D Harding, C Weinberg, A Silverman, RH Douek, DC Margolis, L Goldstein, DB Carrington, M Goedert, JJ
dc.coverage.spatial United States 2011-06-21T17:27:22Z 2010-11-01
dc.identifier.citation J Infect Dis, 2010, 202 Suppl 3 pp. S333 - S338
dc.description.abstract Both clinical experience and a growing medical literature indicate that some persons who have been exposed to human immunodeficiency virus (HIV) infection remain uninfected. Although in some instances this may represent good fortune, cohorts of uninfected persons have been reported who are considered at high risk for infection. In these cohorts a variety of characteristics have been proposed as mediating protection, but to date only the 32–base pair deletion in the chemokine (C‐C motif) receptor 5 gene, which results in complete failure of cell surface expression of this coreceptor, has been associated with high‐level protection from HIV infection. With this in mind, there are probably many other factors that may individually or in combination provide some level of protection from acquisition of HIV infection. Because some of these factors are probably incompletely protective or inconsistently active, identifying them with confidence will be difficult. Nonetheless, clarifying the determinants of protection against HIV infection is a high priority that will require careful selection of high‐risk uninfected cohorts, who should undergo targeted studies of plausible mediators and broad screening for unexpected determinants of protection.
dc.format.extent S333 - S338
dc.language eng
dc.language.iso en_US en_US
dc.relation.ispartof J Infect Dis
dc.relation.isversionof 10.1086/655967
dc.subject HIV
dc.subject HIV Infections
dc.subject Humans
dc.subject Immunity, Innate
dc.subject Receptors, CCR5
dc.subject Receptors, HIV
dc.title Determinants of protection among HIV‐exposed seronegative persons: an overview.
dc.title.alternative en_US
dc.type Journal Article
dc.description.version Version of Record en_US 2010-11-1 en_US
duke.description.endpage S338 en_US
duke.description.issue en_US
duke.description.startpage S333 en_US
duke.description.volume 202 en_US
dc.relation.journal Journal of Infectious Diseases en_US
pubs.organisational-group /Duke
pubs.organisational-group /Duke/Institutes and Provost's Academic Units
pubs.organisational-group /Duke/Institutes and Provost's Academic Units/University Institutes and Centers
pubs.organisational-group /Duke/Institutes and Provost's Academic Units/University Institutes and Centers/Duke Institute for Brain Sciences
pubs.organisational-group /Duke/School of Medicine
pubs.organisational-group /Duke/School of Medicine/Basic Science Departments
pubs.organisational-group /Duke/School of Medicine/Basic Science Departments/Molecular Genetics and Microbiology
pubs.organisational-group /Duke/School of Medicine/Institutes and Centers
pubs.organisational-group /Duke/School of Medicine/Institutes and Centers/Duke Center for Human Genome Variation
pubs.organisational-group /Duke/School of Medicine/Institutes and Centers/Duke Clinical Research Institute
pubs.publication-status Published
pubs.volume 202 Suppl 3
dc.identifier.eissn 1537-6613

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