Show simple item record Sun, HY Alexander, BD Lortholary, O Dromer, F Forrest, GN Lyon, GM Somani, J Gupta, KL del Busto, R Pruett, TL Sifri, CD Limaye, AP John, GT Klintmalm, GB Pursell, K Stosor, V Morris, MI Dowdy, LA Munoz, P Kalil, AC Garcia-Diaz, J Orloff, SL House, AA Houston, SH Wray, D Huprikar, S Johnson, LB Humar, A Razonable, RR Fisher, RA Husain, S Wagener, MM Singh, N Cryptococcal Collaborative Transplant Study Group
dc.coverage.spatial United States 2011-06-21T17:27:22Z 2010-11-01
dc.identifier.citation Clin Infect Dis, 2010, 51 (9), pp. 1062 - 1069
dc.description.abstract BACKGROUND: Cryptococcosis occurring ≤30 days after transplantation is an unusual event, and its characteristics are not known. METHODS: Patients included 175 solid-organ transplant (SOT) recipients with cryptococcosis in a multicenter cohort. Very early-onset and late-onset cryptococcosis were defined as disease occurring ≤30 days or >30 days after transplantation, respectively. RESULTS: Very early-onset disease developed in 9 (5%) of the 175 patients at a mean of 5.7 days after transplantation. Overall, 55.6% (5 of 9) of the patients with very early-onset disease versus 25.9% (43 of 166) of the patients with late-onset disease were liver transplant recipients (P = .05). Very early cases were more likely to present with disease at unusual locations, including transplanted allograft and surgical fossa/site infections (55.6% vs 7.2%; P < .001). Two very early cases with onset on day 1 after transplantation (in a liver transplant recipient with Cryptococcus isolated from the lung and a heart transplant recipient with fungemia) likely were the result of undetected pretransplant disease. An additional 5 cases involving the allograft or surgical sites were likely the result of donor&#x2010;acquired infection. CONCLUSIONS: A subset of SOT recipients with cryptococcosis present very early after transplantation with disease that appears to occur preferentially in liver transplant recipients and involves unusual sites, such as the transplanted organ or the surgical site. These patients may have unrecognized pretransplant or donor-derived cryptococcosis.
dc.format.extent 1062 - 1069
dc.language eng
dc.language.iso en_US en_US
dc.relation.ispartof Clin Infect Dis
dc.relation.isversionof 10.1086/656584
dc.subject Adult
dc.subject Aged
dc.subject Cohort Studies
dc.subject Cryptococcosis
dc.subject Cryptococcus
dc.subject Female
dc.subject Humans
dc.subject Male
dc.subject Middle Aged
dc.subject Postoperative Complications
dc.subject Time Factors
dc.subject Tissue Donors
dc.subject Transplants
dc.title Unrecognized pretransplant and donor‐derived cryptococcal disease in organ transplant recipients.
dc.title.alternative en_US
dc.type Journal Article
dc.description.version Version of Record en_US 2010-11-1 en_US
duke.description.endpage 1069 en_US
duke.description.issue 9 en_US
duke.description.startpage 1062 en_US
duke.description.volume 51 en_US
dc.relation.journal Clinical Infectious Diseases en_US
pubs.issue 9
pubs.organisational-group /Duke
pubs.organisational-group /Duke/School of Medicine
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments/Medicine
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments/Medicine/Medicine, Infectious Diseases
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments/Pathology
pubs.publication-status Published
pubs.volume 51
dc.identifier.eissn 1537-6591

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