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A dual role for ErbB2 signaling in cardiac trabeculation.

dc.contributor.author Liu, J
dc.contributor.author Bressan, M
dc.contributor.author Hassel, D
dc.contributor.author Huisken, J
dc.contributor.author Staudt, D
dc.contributor.author Kikuchi, K
dc.contributor.author Poss, KD
dc.contributor.author Mikawa, T
dc.contributor.author Stainier, DY
dc.coverage.spatial England
dc.date.accessioned 2011-06-21T17:27:31Z
dc.date.issued 2010-11
dc.identifier http://www.ncbi.nlm.nih.gov/pubmed/20978078
dc.identifier 137/22/3867
dc.identifier.uri https://hdl.handle.net/10161/4177
dc.description.abstract Cardiac trabeculation is a crucial morphogenetic process by which clusters of ventricular cardiomyocytes extrude and expand into the cardiac jelly to form sheet-like projections. Although it has been suggested that cardiac trabeculae enhance cardiac contractility and intra-ventricular conduction, their exact function in heart development has not been directly addressed. We found that in zebrafish erbb2 mutants, which we show completely lack cardiac trabeculae, cardiac function is significantly compromised, with mutant hearts exhibiting decreased fractional shortening and an immature conduction pattern. To begin to elucidate the cellular mechanisms of ErbB2 function in cardiac trabeculation, we analyzed erbb2 mutant hearts more closely and found that loss of ErbB2 activity resulted in a complete absence of cardiomyocyte proliferation during trabeculation stages. In addition, based on data obtained from proliferation, lineage tracing and transplantation studies, we propose that cardiac trabeculation is initiated by directional cardiomyocyte migration rather than oriented cell division, and that ErbB2 cell-autonomously regulates this process.
dc.language eng
dc.language.iso en_US
dc.relation.ispartof Development
dc.relation.isversionof 10.1242/dev.053736
dc.subject Animals
dc.subject Cell Movement
dc.subject Cell Proliferation
dc.subject Heart
dc.subject Morphogenesis
dc.subject Myocardium
dc.subject Myocytes, Cardiac
dc.subject Receptor, ErbB-2
dc.subject Zebrafish
dc.title A dual role for ErbB2 signaling in cardiac trabeculation.
dc.title.alternative
dc.type Journal article
dc.description.version Version of Record
duke.date.pubdate 2010-11-15
duke.description.issue 22
duke.description.volume 137
dc.relation.journal Development
pubs.author-url http://www.ncbi.nlm.nih.gov/pubmed/20978078
pubs.begin-page 3867
pubs.end-page 3875
pubs.issue 22
pubs.organisational-group Basic Science Departments
pubs.organisational-group Biology
pubs.organisational-group Cell Biology
pubs.organisational-group Clinical Science Departments
pubs.organisational-group Duke
pubs.organisational-group Duke Cancer Institute
pubs.organisational-group Institutes and Centers
pubs.organisational-group Medicine
pubs.organisational-group Medicine, Cardiology
pubs.organisational-group School of Medicine
pubs.organisational-group Trinity College of Arts & Sciences
pubs.publication-status Published
pubs.volume 137
dc.identifier.eissn 1477-9129


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