Animal models of soft-tissue sarcoma.
Abstract
Soft-tissue sarcomas (STSs) are rare mesenchymal tumors that arise from muscle, fat
and connective tissue. Currently, over 75 subtypes of STS are recognized. The rarity
and heterogeneity of patient samples complicate clinical investigations into sarcoma
biology. Model organisms might provide traction to our understanding and treatment
of the disease. Over the past 10 years, many successful animal models of STS have
been developed, primarily genetically engineered mice and zebrafish. These models
are useful for studying the relevant oncogenes, signaling pathways and other cell
changes involved in generating STSs. Recently, these model systems have become preclinical
platforms in which to evaluate new drugs and treatment regimens. Thus, animal models
are useful surrogates for understanding STS disease susceptibility and pathogenesis
as well as for testing potential therapeutic strategies.
Type
Journal articlePermalink
https://hdl.handle.net/10161/4183Published Version (Please cite this version)
10.1242/dmm.005223Publication Info
Dodd, Rebecca D; Mito, Jeffery K; & Kirsch, David G (2010). Animal models of soft-tissue sarcoma. Dis Model Mech, 3(9-10). pp. 557-566. 10.1242/dmm.005223. Retrieved from https://hdl.handle.net/10161/4183.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
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Show full item recordScholars@Duke
David Guy Kirsch
Barbara Levine University Distinguished Professor
My clinical interests are the multi-modality care of patients with bone and soft tissue
sarcomas and developing new sarcoma therapies. My laboratory interests include utilizing
mouse models of cancer to study cancer and radiation biology in order to develop new
cancer therapies in the pre-clinical setting.

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