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Animal models of soft-tissue sarcoma.

dc.contributor.author Dodd, Rebecca D
dc.contributor.author Mito, Jeffery K
dc.contributor.author Kirsch, David G
dc.coverage.spatial England
dc.date.accessioned 2011-06-21T17:27:33Z
dc.date.issued 2010-09
dc.identifier http://www.ncbi.nlm.nih.gov/pubmed/20713645
dc.identifier dmm.005223
dc.identifier.uri https://hdl.handle.net/10161/4183
dc.description.abstract Soft-tissue sarcomas (STSs) are rare mesenchymal tumors that arise from muscle, fat and connective tissue. Currently, over 75 subtypes of STS are recognized. The rarity and heterogeneity of patient samples complicate clinical investigations into sarcoma biology. Model organisms might provide traction to our understanding and treatment of the disease. Over the past 10 years, many successful animal models of STS have been developed, primarily genetically engineered mice and zebrafish. These models are useful for studying the relevant oncogenes, signaling pathways and other cell changes involved in generating STSs. Recently, these model systems have become preclinical platforms in which to evaluate new drugs and treatment regimens. Thus, animal models are useful surrogates for understanding STS disease susceptibility and pathogenesis as well as for testing potential therapeutic strategies.
dc.language eng
dc.language.iso en_US
dc.publisher The Company of Biologists
dc.relation.ispartof Dis Model Mech
dc.relation.isversionof 10.1242/dmm.005223
dc.subject Animals
dc.subject Disease Models, Animal
dc.subject Humans
dc.subject Karyotyping
dc.subject Sarcoma
dc.subject Transcription Factors
dc.title Animal models of soft-tissue sarcoma.
dc.title.alternative
dc.type Journal article
duke.contributor.id Kirsch, David G|0039826
dc.description.version Version of Record
duke.date.pubdate 2010-10-sep
duke.description.issue 10-Sep
duke.description.volume 3
dc.relation.journal Disease Models & Mechanisms
pubs.author-url http://www.ncbi.nlm.nih.gov/pubmed/20713645
pubs.begin-page 557
pubs.end-page 566
pubs.issue 9-10
pubs.organisational-group Basic Science Departments
pubs.organisational-group Clinical Science Departments
pubs.organisational-group Duke
pubs.organisational-group Duke Cancer Institute
pubs.organisational-group Institutes and Centers
pubs.organisational-group Pharmacology & Cancer Biology
pubs.organisational-group Radiation Oncology
pubs.organisational-group School of Medicine
pubs.publication-status Published
pubs.volume 3
dc.identifier.eissn 1754-8411


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