Crosstalk rejection in full-field optical coherence tomography using spatially incoherent illumination with a partially coherent source
Abstract
The recent advent of ultra high frame rate cameras gives rise to the possibility of
constructing swept source full-field OCT systems with achievable volume rates approaching
10Hz and net A-scan rates approaching 10MHz. Unfortunately, when illuminated with
partially coherent light, full-field OCT in turbid media suffers resolution and SNR
degradation from coherent multiple scattering, a phenomenon commonly referred to as
crosstalk. As a result, most FFOCT systems employ thermal sources, which provide spatially
incoherent illumination to achieve crosstalk rejection. However, these thermal sources
preclude the use of swept source lasers. In this work, we demonstrate the use of a
carefully configured FFOCT system employing multimode fiber in the illumination arm
to reduce the spatial coherence of a partially coherent source. By reducing the coherence
area below the system resolution, the illumination becomes effectively spatially incoherent
and crosstalk is largely rejected. We compare FFOCT images of a USAF test chart positioned
beneath both transparent and turbid phantoms using both illumination schemes. © 2010
Copyright SPIE - The International Society for Optical Engineering.
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https://hdl.handle.net/10161/4221Published Version (Please cite this version)
10.1117/12.843391Publication Info
Dhalla, Al-Hafeez; Migacz, Justin V; & Izatt, Joseph A (2010). Crosstalk rejection in full-field optical coherence tomography using spatially incoherent
illumination with a partially coherent source. Progress in Biomedical Optics and Imaging - Proceedings of SPIE, 7554. pp. 2305-2307. 10.1117/12.843391. Retrieved from https://hdl.handle.net/10161/4221.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
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Show full item recordScholars@Duke
Al-Hafeez Z Dhalla
Assistant Research Professor in the Department of Biomedical Engineering
My research focuses on the application of optical technologies for non-invasive, high-resolution
imaging of biological tissues. In particular, our laboratory develops optical coherence
tomography (OCT), scanning laser ophthalmoscopy (SLO), light detection and ranging
(LiDAR) and other optical imaging technologies for applications in the diagnosis and
treatment of disease, particularly diseases of the eye. My work focuses not only on
the engineering and technical development of novel imagin
Joseph A. Izatt
Michael J. Fitzpatrick Distinguished Professor of Engineering
My research centers on the development and application of cutting-edge optical technologies
for non-invasive, high-resolution imaging and sensing in living biological tissues.
Our laboratory is recognized for foundational contributions to optical coherence-based
approaches for in vivo sub-surface microscopic tissue imaging, particularly optical
coherence tomography (OCT) which has become a standard of care in ophthalmology and
other clinical specialties. The technologies we employ includ
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