Crosstalk rejection in full-field optical coherence tomography using spatially incoherent illumination with a partially coherent source
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The recent advent of ultra high frame rate cameras gives rise to the possibility of constructing swept source full-field OCT systems with achievable volume rates approaching 10Hz and net A-scan rates approaching 10MHz. Unfortunately, when illuminated with partially coherent light, full-field OCT in turbid media suffers resolution and SNR degradation from coherent multiple scattering, a phenomenon commonly referred to as crosstalk. As a result, most FFOCT systems employ thermal sources, which provide spatially incoherent illumination to achieve crosstalk rejection. However, these thermal sources preclude the use of swept source lasers. In this work, we demonstrate the use of a carefully configured FFOCT system employing multimode fiber in the illumination arm to reduce the spatial coherence of a partially coherent source. By reducing the coherence area below the system resolution, the illumination becomes effectively spatially incoherent and crosstalk is largely rejected. We compare FFOCT images of a USAF test chart positioned beneath both transparent and turbid phantoms using both illumination schemes. © 2010 Copyright SPIE - The International Society for Optical Engineering.
Published Version (Please cite this version)10.1117/12.843391
Publication InfoDhalla, Al-Hafeez; Migacz, Justin V; & Izatt, Joseph A (2010). Crosstalk rejection in full-field optical coherence tomography using spatially incoherent illumination with a partially coherent source. Progress in Biomedical Optics and Imaging - Proceedings of SPIE, 7554. pp. 2305-2307. 10.1117/12.843391. Retrieved from https://hdl.handle.net/10161/4221.
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Assist Research Professor in the Department of Biomedical Engineering
My research centers on the application of optical technologies for non-invasive, high-resolution imaging of biological tissues. In particular, I focus on applications of optical coherence tomography (OCT) and scanning laser ophthalmoscopy (SLO) in the diagnosis and treatment of diseases of the eye. My work focuses not only on the engineering and technical development of novel imaging technologies, but also the preparation of these technologies for commercialization through clinical validat
Michael J. Fitzpatrick Distinguished Professor of Engineering in the Edmund T. Pratt, Jr. School of Engineering
Biophotonics is concerned with the application of cutting-edge optoelectronic technologies to problems in the biomedical sciences. My research centers on the application of optical technologies for non-invasive, high-resolution imaging and sensing in living biological tissues. The technologies we use in my laboratory include acousto-optic and integrated-optic devices, femtosecond lasers, and ultrabroadband fiber optic telecommunications equipment. The applications of the systems we build incl
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