Intraoperative spectral domain optical coherence tomography for vitreoretinal surgery.
Abstract
We demonstrate in vivo human retinal imaging using an intraoperative microscope-mounted
optical coherence tomography system (MMOCT). Our optomechanical design adapts an Oculus
Binocular Indirect Ophthalmo Microscope (BIOM3), suspended from a Leica ophthalmic
surgical microscope, with spectral domain optical coherence tomography (SD-OCT) scanning
and relay optics. The MMOCT enables wide-field noncontact real-time cross-sectional
imaging of retinal structure, allowing for SD-OCT augmented intrasurgical microscopy
for intraocular visualization. We experimentally quantify the axial and lateral resolution
of the MMOCT and demonstrate fundus imaging at a 20Hz frame rate.
Type
Journal articleSubject
AnimalsHumans
Imaging, Three-Dimensional
Retina
Retinoscopes
Swine
Tomography, Optical Coherence
Vitreoretinal Surgery
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https://hdl.handle.net/10161/4228Collections
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Show full item recordScholars@Duke
Joseph A. Izatt
Michael J. Fitzpatrick Distinguished Professor of Engineering in the Edmund T. Pratt,
Jr. School of Engineering
My research centers on the development and application of cutting-edge optical technologies
for non-invasive, high-resolution imaging and sensing in living biological tissues.
Our laboratory is recognized for foundational contributions to optical coherence-based
approaches for in vivo sub-surface microscopic tissue imaging, particularly optical
coherence tomography (OCT) which has become a standard of care in ophthalmology and
other clinical specialties. The technologies we employ includ
Cynthia Ann Toth
Joseph A.C. Wadsworth Distinguished Professor of Ophthalmology
RESEARCH INTERESTS Dr. Toth specializes in the evaluation and surgical treatment
of vitreoretinal diseases in infants, children and adults, and in novel research resulting
in the clinical application of optical coherence tomography (OCT) imaging in surgery
and at the bedside. Her clinical interests and skills include the surgical treatment
of macular diseases (such as, macular hole, epiretinal membrane and vitreomacular
traction), retinal detachment, proliferative diabetic ret
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