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A low-cost, portable, and quantitative spectral imaging system for application to biological tissues.

dc.contributor.author Fu, Henry L
dc.contributor.author Yu, Bing
dc.contributor.author Lo, Justin Y
dc.contributor.author Palmer, Greg M
dc.contributor.author Kuech, Thomas F
dc.contributor.author Ramanujam, Nimmi
dc.coverage.spatial United States
dc.date.accessioned 2011-06-21T17:27:43Z
dc.date.issued 2010-06-07
dc.identifier http://www.ncbi.nlm.nih.gov/pubmed/20588390
dc.identifier 199840
dc.identifier.uri https://hdl.handle.net/10161/4239
dc.description.abstract The ability of diffuse reflectance spectroscopy to extract quantitative biological composition of tissues has been used to discern tissue types in both pre-clinical and clinical cancer studies. Typically, diffuse reflectance spectroscopy systems are designed for single-point measurements. Clinically, an imaging system would provide valuable spatial information on tissue composition. While it is feasible to build a multiplexed fiber-optic probe based spectral imaging system, these systems suffer from drawbacks with respect to cost and size. To address these we developed a compact and low cost system using a broadband light source with an 8-slot filter wheel for illumination and silicon photodiodes for detection. The spectral imaging system was tested on a set of tissue mimicking liquid phantoms which yielded an optical property extraction accuracy of 6.40 +/- 7.78% for the absorption coefficient (micro(a)) and 11.37 +/- 19.62% for the wavelength-averaged reduced scattering coefficient (micro(s)').
dc.language eng
dc.language.iso en_US
dc.publisher The Optical Society
dc.relation.ispartof Opt Express
dc.subject Computer Simulation
dc.subject Imaging, Three-Dimensional
dc.subject Optical Phenomena
dc.subject Phantoms, Imaging
dc.subject Spectrum Analysis
dc.title A low-cost, portable, and quantitative spectral imaging system for application to biological tissues.
dc.title.alternative
dc.type Journal article
duke.contributor.id Fu, Henry L|0434225
duke.contributor.id Palmer, Greg M|0375353
dc.description.version Version of Record
duke.date.pubdate 2010-6-7
duke.description.issue 12
duke.description.volume 18
dc.relation.journal Optics Express
pubs.author-url http://www.ncbi.nlm.nih.gov/pubmed/20588390
pubs.begin-page 12630
pubs.end-page 12645
pubs.issue 12
pubs.organisational-group Basic Science Departments
pubs.organisational-group Biomedical Engineering
pubs.organisational-group Clinical Science Departments
pubs.organisational-group Duke
pubs.organisational-group Duke Cancer Institute
pubs.organisational-group Duke Science & Society
pubs.organisational-group Global Health Institute
pubs.organisational-group Initiatives
pubs.organisational-group Institutes and Centers
pubs.organisational-group Institutes and Provost's Academic Units
pubs.organisational-group Pharmacology & Cancer Biology
pubs.organisational-group Pratt School of Engineering
pubs.organisational-group Radiation Oncology
pubs.organisational-group School of Medicine
pubs.organisational-group University Institutes and Centers
pubs.publication-status Published
pubs.volume 18
dc.identifier.eissn 1094-4087
duke.contributor.orcid Palmer, Greg M|0000-0003-2955-8297


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