dc.contributor.author |
Fu, Henry L |
|
dc.contributor.author |
Yu, Bing |
|
dc.contributor.author |
Lo, Justin Y |
|
dc.contributor.author |
Palmer, Greg M |
|
dc.contributor.author |
Kuech, Thomas F |
|
dc.contributor.author |
Ramanujam, Nimmi |
|
dc.coverage.spatial |
United States |
|
dc.date.accessioned |
2011-06-21T17:27:43Z |
|
dc.date.issued |
2010-06-07 |
|
dc.identifier |
http://www.ncbi.nlm.nih.gov/pubmed/20588390 |
|
dc.identifier |
199840 |
|
dc.identifier.uri |
https://hdl.handle.net/10161/4239 |
|
dc.description.abstract |
The ability of diffuse reflectance spectroscopy to extract quantitative biological
composition of tissues has been used to discern tissue types in both pre-clinical
and clinical cancer studies. Typically, diffuse reflectance spectroscopy systems are
designed for single-point measurements. Clinically, an imaging system would provide
valuable spatial information on tissue composition. While it is feasible to build
a multiplexed fiber-optic probe based spectral imaging system, these systems suffer
from drawbacks with respect to cost and size. To address these we developed a compact
and low cost system using a broadband light source with an 8-slot filter wheel for
illumination and silicon photodiodes for detection. The spectral imaging system was
tested on a set of tissue mimicking liquid phantoms which yielded an optical property
extraction accuracy of 6.40 +/- 7.78% for the absorption coefficient (micro(a)) and
11.37 +/- 19.62% for the wavelength-averaged reduced scattering coefficient (micro(s)').
|
|
dc.language |
eng |
|
dc.language.iso |
en_US |
|
dc.publisher |
The Optical Society |
|
dc.relation.ispartof |
Opt Express |
|
dc.subject |
Computer Simulation |
|
dc.subject |
Imaging, Three-Dimensional |
|
dc.subject |
Optical Phenomena |
|
dc.subject |
Phantoms, Imaging |
|
dc.subject |
Spectrum Analysis |
|
dc.title |
A low-cost, portable, and quantitative spectral imaging system for application to
biological tissues.
|
|
dc.title.alternative |
|
|
dc.type |
Journal article |
|
duke.contributor.id |
Fu, Henry L|0434225 |
|
duke.contributor.id |
Palmer, Greg M|0375353 |
|
dc.description.version |
Version of Record |
|
duke.date.pubdate |
2010-6-7 |
|
duke.description.issue |
12 |
|
duke.description.volume |
18 |
|
dc.relation.journal |
Optics Express |
|
pubs.author-url |
http://www.ncbi.nlm.nih.gov/pubmed/20588390 |
|
pubs.begin-page |
12630 |
|
pubs.end-page |
12645 |
|
pubs.issue |
12 |
|
pubs.organisational-group |
Basic Science Departments |
|
pubs.organisational-group |
Biomedical Engineering |
|
pubs.organisational-group |
Clinical Science Departments |
|
pubs.organisational-group |
Duke |
|
pubs.organisational-group |
Duke Cancer Institute |
|
pubs.organisational-group |
Duke Science & Society |
|
pubs.organisational-group |
Global Health Institute |
|
pubs.organisational-group |
Initiatives |
|
pubs.organisational-group |
Institutes and Centers |
|
pubs.organisational-group |
Institutes and Provost's Academic Units |
|
pubs.organisational-group |
Pharmacology & Cancer Biology |
|
pubs.organisational-group |
Pratt School of Engineering |
|
pubs.organisational-group |
Radiation Oncology |
|
pubs.organisational-group |
School of Medicine |
|
pubs.organisational-group |
University Institutes and Centers |
|
pubs.publication-status |
Published |
|
pubs.volume |
18 |
|
dc.identifier.eissn |
1094-4087 |
|
duke.contributor.orcid |
Palmer, Greg M|0000-0003-2955-8297 |
|