dc.contributor.author |
Bender, Janelle E |
|
dc.contributor.author |
Shang, Allan B |
|
dc.contributor.author |
Moretti, Eugene W |
|
dc.contributor.author |
Yu, Bing |
|
dc.contributor.author |
Richards, Lisa M |
|
dc.contributor.author |
Ramanujam, Nirmala |
|
dc.coverage.spatial |
United States |
|
dc.date.accessioned |
2011-06-21T17:27:43Z |
|
dc.date.issued |
2009-12-21 |
|
dc.identifier |
https://www.ncbi.nlm.nih.gov/pubmed/20052047 |
|
dc.identifier |
192701 |
|
dc.identifier.uri |
https://hdl.handle.net/10161/4243 |
|
dc.description.abstract |
We conducted a pilot study on 10 patients undergoing general surgery to test the feasibility
of diffuse reflectance spectroscopy in the visible wavelength range as a noninvasive
monitoring tool for blood loss during surgery. Ratios of raw diffuse reflectance at
wavelength pairs were tested as a first-pass for estimating hemoglobin concentration.
Ratios can be calculated easily and rapidly with limited post-processing, and so this
can be considered a near real-time monitoring device. We found the best hemoglobin
correlations were when ratios at isosbestic points of oxy- and deoxyhemoglobin were
used, specifically 529/500 nm. Baseline subtraction improved correlations, specifically
at 520/509 nm. These results demonstrate proof-of-concept for the ability of this
noninvasive device to monitor hemoglobin concentration changes due to surgical blood
loss. The 529/500 nm ratio also appears to account for variations in probe pressure,
as determined from measurements on two volunteers.
|
|
dc.language |
eng |
|
dc.language.iso |
en_US |
|
dc.publisher |
The Optical Society |
|
dc.relation.ispartof |
Opt Express |
|
dc.subject |
Biomarkers |
|
dc.subject |
Blood Chemical Analysis |
|
dc.subject |
Blood Loss, Surgical |
|
dc.subject |
Diagnosis, Computer-Assisted |
|
dc.subject |
Feasibility Studies |
|
dc.subject |
Hemoglobins |
|
dc.subject |
Humans |
|
dc.subject |
Oxygen |
|
dc.subject |
Pilot Projects |
|
dc.subject |
Postoperative Hemorrhage |
|
dc.subject |
Reproducibility of Results |
|
dc.subject |
Sensitivity and Specificity |
|
dc.subject |
Spectrophotometry, Ultraviolet |
|
dc.title |
Noninvasive monitoring of tissue hemoglobin using UV-VIS diffuse reflectance spectroscopy:
a pilot study.
|
|
dc.title.alternative |
|
|
dc.type |
Journal article |
|
duke.contributor.id |
Moretti, Eugene W|0099540 |
|
dc.description.version |
Version of Record |
|
duke.date.pubdate |
2009-12-21 |
|
duke.description.issue |
26 |
|
duke.description.volume |
17 |
|
dc.relation.journal |
Optics Express |
|
pubs.author-url |
https://www.ncbi.nlm.nih.gov/pubmed/20052047 |
|
pubs.begin-page |
23396 |
|
pubs.end-page |
23409 |
|
pubs.issue |
26 |
|
pubs.organisational-group |
Anesthesiology |
|
pubs.organisational-group |
Anesthesiology, General, Vascular, High Risk Transplant & Critical Care |
|
pubs.organisational-group |
Basic Science Departments |
|
pubs.organisational-group |
Biomedical Engineering |
|
pubs.organisational-group |
Clinical Science Departments |
|
pubs.organisational-group |
Duke |
|
pubs.organisational-group |
Duke Cancer Institute |
|
pubs.organisational-group |
Duke Science & Society |
|
pubs.organisational-group |
Initiatives |
|
pubs.organisational-group |
Institutes and Centers |
|
pubs.organisational-group |
Institutes and Provost's Academic Units |
|
pubs.organisational-group |
Nursing |
|
pubs.organisational-group |
Pharmacology & Cancer Biology |
|
pubs.organisational-group |
Pratt School of Engineering |
|
pubs.organisational-group |
School of Medicine |
|
pubs.organisational-group |
School of Nursing |
|
pubs.publication-status |
Published |
|
pubs.volume |
17 |
|
dc.identifier.eissn |
1094-4087 |
|