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Noninvasive monitoring of tissue hemoglobin using UV-VIS diffuse reflectance spectroscopy: a pilot study.

dc.contributor.author Bender, Janelle E
dc.contributor.author Shang, Allan B
dc.contributor.author Moretti, Eugene W
dc.contributor.author Yu, Bing
dc.contributor.author Richards, Lisa M
dc.contributor.author Ramanujam, Nirmala
dc.coverage.spatial United States
dc.date.accessioned 2011-06-21T17:27:43Z
dc.date.issued 2009-12-21
dc.identifier https://www.ncbi.nlm.nih.gov/pubmed/20052047
dc.identifier 192701
dc.identifier.uri https://hdl.handle.net/10161/4243
dc.description.abstract We conducted a pilot study on 10 patients undergoing general surgery to test the feasibility of diffuse reflectance spectroscopy in the visible wavelength range as a noninvasive monitoring tool for blood loss during surgery. Ratios of raw diffuse reflectance at wavelength pairs were tested as a first-pass for estimating hemoglobin concentration. Ratios can be calculated easily and rapidly with limited post-processing, and so this can be considered a near real-time monitoring device. We found the best hemoglobin correlations were when ratios at isosbestic points of oxy- and deoxyhemoglobin were used, specifically 529/500 nm. Baseline subtraction improved correlations, specifically at 520/509 nm. These results demonstrate proof-of-concept for the ability of this noninvasive device to monitor hemoglobin concentration changes due to surgical blood loss. The 529/500 nm ratio also appears to account for variations in probe pressure, as determined from measurements on two volunteers.
dc.language eng
dc.language.iso en_US
dc.publisher The Optical Society
dc.relation.ispartof Opt Express
dc.subject Biomarkers
dc.subject Blood Chemical Analysis
dc.subject Blood Loss, Surgical
dc.subject Diagnosis, Computer-Assisted
dc.subject Feasibility Studies
dc.subject Hemoglobins
dc.subject Humans
dc.subject Oxygen
dc.subject Pilot Projects
dc.subject Postoperative Hemorrhage
dc.subject Reproducibility of Results
dc.subject Sensitivity and Specificity
dc.subject Spectrophotometry, Ultraviolet
dc.title Noninvasive monitoring of tissue hemoglobin using UV-VIS diffuse reflectance spectroscopy: a pilot study.
dc.title.alternative
dc.type Journal article
duke.contributor.id Moretti, Eugene W|0099540
dc.description.version Version of Record
duke.date.pubdate 2009-12-21
duke.description.issue 26
duke.description.volume 17
dc.relation.journal Optics Express
pubs.author-url https://www.ncbi.nlm.nih.gov/pubmed/20052047
pubs.begin-page 23396
pubs.end-page 23409
pubs.issue 26
pubs.organisational-group Anesthesiology
pubs.organisational-group Anesthesiology, General, Vascular, High Risk Transplant & Critical Care
pubs.organisational-group Basic Science Departments
pubs.organisational-group Biomedical Engineering
pubs.organisational-group Clinical Science Departments
pubs.organisational-group Duke
pubs.organisational-group Duke Cancer Institute
pubs.organisational-group Duke Science & Society
pubs.organisational-group Initiatives
pubs.organisational-group Institutes and Centers
pubs.organisational-group Institutes and Provost's Academic Units
pubs.organisational-group Nursing
pubs.organisational-group Pharmacology & Cancer Biology
pubs.organisational-group Pratt School of Engineering
pubs.organisational-group School of Medicine
pubs.organisational-group School of Nursing
pubs.publication-status Published
pubs.volume 17
dc.identifier.eissn 1094-4087


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