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Effect of lithotripter focal width on stone comminution in shock wave lithotripsy.

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Date
2010-04
Authors
Qin, Jun
Simmons, W Neal
Sankin, Georgy
Zhong, Pei
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668
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Abstract
Using a reflector insert, the original HM-3 lithotripter field at 20 kV was altered significantly with the peak positive pressure (p(+)) in the focal plane increased from 49 to 87 MPa while the -6 dB focal width decreased concomitantly from 11 to 4 mm. Using the original reflector, p(+) of 33 MPa with a -6 dB focal width of 18 mm were measured in a pre-focal plane 15-mm proximal to the lithotripter focus. However, the acoustic pulse energy delivered to a 28-mm diameter area around the lithotripter axis was comparable ( approximately 120 mJ). For all three exposure conditions, similar stone comminution ( approximately 70%) was produced in a mesh holder of 15 mm after 250 shocks. In contrast, stone comminution produced by the modified reflector either in a 15-mm finger cot (45%) or in a 30-mm membrane holder (14%) was significantly reduced from the corresponding values (56% and 26%) produced by the original reflector (no statistically significant differences were observed between the focal and pre-focal planes). These observations suggest that a low-pressure/broad focal width lithotripter field will produce better stone comminution than its counterpart with high-pressure/narrow focal width under clinically relevant in vitro comminution conditions.
Type
Journal article
Subject
Acoustics
Calculi
Equipment Design
Lithotripsy
Materials Testing
Models, Theoretical
Motion
Phantoms, Imaging
Pressure
Time Factors
Transducers, Pressure
Permalink
https://hdl.handle.net/10161/4244
Published Version (Please cite this version)
10.1121/1.3308409
Publication Info
Qin, Jun; Simmons, W Neal; Sankin, Georgy; & Zhong, Pei (2010). Effect of lithotripter focal width on stone comminution in shock wave lithotripsy. J Acoust Soc Am, 127(4). pp. 2635-2645. 10.1121/1.3308409. Retrieved from https://hdl.handle.net/10161/4244.
This is constructed from limited available data and may be imprecise. To cite this article, please review & use the official citation provided by the journal.
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Scholars@Duke

Simmons

Walter Neal Simmons

Gendell Family Professor of the Practice
Zhong

Pei Zhong

Professor in the Thomas Lord Department of Mechanical Engineering and Materials Science
My research focuses on engineering and technology development with applications in the non-invasive or minimally invasive treatment of kidney stone disease via shock wave and laser lithotripsy, high-intensity focused ultrasound (HIFU) and immunotherapy for cancer treatment, acoustic and optical cavitation, and ultrasound neuromodulation via sonogenetics.  We are taking an integrated and translational approach that combines fundamental research with engineering and applied technol
Alphabetical list of authors with Scholars@Duke profiles.
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