Pulsating tandem microbubble for localized and directional single-cell membrane poration.
Abstract
The interaction of laser-generated tandem microbubble (maximum diameter of about 50 μm)
with single (rat mammary carcinoma) cells is investigated in a 25-μm liquid layer.
Antiphase and coupled oscillation of the tandem microbubble leads to the formation
of alternating, directional microjets (with max microstreaming velocity of 10 m/s)
and vortices (max vorticity of 350 000 s{-1}) in opposite directions. Localized and
directional membrane poration (200 nm to 2 μm in pore size) can be produced by the
tandem microbubble in an orientation and proximity-dependent manner, which is absent
from a single oscillating microbubble of comparable size and at the same stand-off
distance.
Type
Journal articleSubject
AnimalsBiological Transport
Cell Line, Tumor
Cell Membrane
Hydrodynamics
Microbubbles
Microscopy
Molecular Imaging
Porosity
Rats
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https://hdl.handle.net/10161/4299Published Version (Please cite this version)
10.1103/PhysRevLett.105.078101Publication Info
Sankin, GN; Yuan, F; & Zhong, P (2010). Pulsating tandem microbubble for localized and directional single-cell membrane poration.
Phys Rev Lett, 105(7). pp. 078101. 10.1103/PhysRevLett.105.078101. Retrieved from https://hdl.handle.net/10161/4299.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
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Show full item recordScholars@Duke
Pei Zhong
Professor in the Department of Mechanical Engineering and Materials Science
My research focuses on engineering and technology development with applications in
the non-invasive or minimally invasive treatment of kidney stone disease via shock
wave and laser lithotripsy, high-intensity focused ultrasound (HIFU) and immunotherapy
for cancer treatment, acoustic and optical cavitation, and ultrasound neuromodulation
via sonogenetics.
We are taking an integrated and translational approach that combines fundamental research
with engineering and applied technol

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