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Pulsating tandem microbubble for localized and directional single-cell membrane poration.

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Date
2010-08-13
Authors
Sankin, GN
Yuan, F
Zhong, P
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Abstract
The interaction of laser-generated tandem microbubble (maximum diameter of about 50  μm) with single (rat mammary carcinoma) cells is investigated in a 25-μm liquid layer. Antiphase and coupled oscillation of the tandem microbubble leads to the formation of alternating, directional microjets (with max microstreaming velocity of 10  m/s) and vortices (max vorticity of 350 000  s{-1}) in opposite directions. Localized and directional membrane poration (200 nm to 2  μm in pore size) can be produced by the tandem microbubble in an orientation and proximity-dependent manner, which is absent from a single oscillating microbubble of comparable size and at the same stand-off distance.
Type
Journal article
Subject
Animals
Biological Transport
Cell Line, Tumor
Cell Membrane
Hydrodynamics
Microbubbles
Microscopy
Molecular Imaging
Porosity
Rats
Permalink
https://hdl.handle.net/10161/4299
Published Version (Please cite this version)
10.1103/PhysRevLett.105.078101
Publication Info
Sankin, GN; Yuan, F; & Zhong, P (2010). Pulsating tandem microbubble for localized and directional single-cell membrane poration. Phys Rev Lett, 105(7). pp. 078101. 10.1103/PhysRevLett.105.078101. Retrieved from https://hdl.handle.net/10161/4299.
This is constructed from limited available data and may be imprecise. To cite this article, please review & use the official citation provided by the journal.
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Scholars@Duke

Zhong

Pei Zhong

Professor in the Department of Mechanical Engineering and Materials Science
My research focuses on engineering and technology development with applications in the non-invasive or minimally invasive treatment of kidney stone disease via shock wave and laser lithotripsy, high-intensity focused ultrasound (HIFU) and immunotherapy for cancer treatment, acoustic and optical cavitation, and ultrasound neuromodulation via sonogenetics.  We are taking an integrated and translational approach that combines fundamental research with engineering and applied technol
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