Epithelial-mesenchymal transitions and hepatocarcinogenesis.
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Epithelial-mesenchymal transitions (EMTs) are believed to play a role in invasion and metastasis of many types of tumors. In this issue of the JCI, Chen et al. show that a gene that has been associated with aggressive biology in hepatocellular carcinomas initiates a molecular cascade that results in EMT.
cdc42 GTP-Binding Protein
Published Version (Please cite this version)10.1172/JCI42615
Publication InfoJou, Janice; & Diehl, Anna Mae (2010). Epithelial-mesenchymal transitions and hepatocarcinogenesis. J Clin Invest, 120(4). pp. 1031-1034. 10.1172/JCI42615. Retrieved from https://hdl.handle.net/10161/4329.
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Florence McAlister Distinguished Professor of Medicine
Our lab has a long standing interest in liver injury and repair. To learn more about the mechanisms that regulate this process, we study cultured cells, animal models of acute and chronic liver damage and samples from patients with various types of liver disease. Our group also conducts clinical trials in patients with chronic liver disease. We are particularly interested in fatty liver diseases, such as alcoholic fatty liver disease and nonalcoholic fatty liver disease (NAFLD). <br