Daily intake of antioxidants in relation to survival among adult patients diagnosed with malignant glioma.
Abstract
BACKGROUND: Malignant glioma is a rare cancer with poor survival. The influence of
diet and antioxidant intake on glioma survival is not well understood. The current
study examines the association between antioxidant intake and survival after glioma
diagnosis. METHODS: Adult patients diagnosed with malignant glioma during 1991-1994
and 1997-2001 were enrolled in a population-based study. Diagnosis was confirmed by
review of pathology specimens. A modified food-frequency questionnaire interview was
completed by each glioma patient or a designated proxy. Intake of each food item was
converted to grams consumed/day. From this nutrient database, 16 antioxidants, calcium,
a total antioxidant index and 3 macronutrients were available for survival analysis.
Cox regression estimated mortality hazard ratios associated with each nutrient and
the antioxidant index adjusting for potential confounders. Nutrient values were categorized
into tertiles. Models were stratified by histology (Grades II, III, and IV) and conducted
for all (including proxy) subjects and for a subset of self-reported subjects. RESULTS:
Geometric mean values for 11 fat-soluble and 6 water-soluble individual antioxidants,
antioxidant index and 3 macronutrients were virtually the same when comparing all
cases (n=748) to self-reported cases only (n=450). For patients diagnosed with Grade
II and Grade III histology, moderate (915.8-2118.3 mcg) intake of fat-soluble lycopene
was associated with poorer survival when compared to low intake (0.0-914.8 mcg), for
self-reported cases only. High intake of vitamin E and moderate/high intake of secoisolariciresinol
among Grade III patients indicated greater survival for all cases. In Grade IV patients,
moderate/high intake of cryptoxanthin and high intake of secoisolariciresinol were
associated with poorer survival among all cases. Among Grade II patients, moderate
intake of water-soluble folate was associated with greater survival for all cases;
high intake of vitamin C and genistein and the highest level of the antioxidant index
were associated with poorer survival for all cases. CONCLUSIONS: The associations
observed in our study suggest that the influence of some antioxidants on survival
following a diagnosis of malignant glioma are inconsistent and vary by histology group.
Further research in a large sample of glioma patients is needed to confirm/refute
our results.
Type
Journal articleSubject
AntioxidantsBrain Neoplasms
California
Databases as Topic
Diet
Diet Records
Female
Glioma
Humans
Interviews as Topic
Kaplan-Meier Estimate
Linear Models
Male
Middle Aged
Neoplasm Staging
Proportional Hazards Models
Risk Assessment
Risk Factors
SEER Program
Time Factors
Treatment Outcome
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https://hdl.handle.net/10161/4355Published Version (Please cite this version)
10.1186/1471-2407-10-215Publication Info
DeLorenze, Gerald N; McCoy, Lucie; Tsai, Ai-Lin; Quesenberry, Charles P; Rice, Terri;
Il'yasova, Dora; & Wrensch, Margaret (2010). Daily intake of antioxidants in relation to survival among adult patients diagnosed
with malignant glioma. BMC Cancer, 10. pp. 215. 10.1186/1471-2407-10-215. Retrieved from https://hdl.handle.net/10161/4355.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
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