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Discontinuation of rLH two days before hCG may increase the number of oocytes retrieved in IVF

dc.contributor.author Copland, Dr Susannah
dc.date.accessioned 2011-06-21T17:29:39Z
dc.date.available 2011-06-21T17:29:39Z
dc.date.issued 2010
dc.identifier.citation Spencer,Jessica B.;Browne,Aimee S.;Copland,Susannah D.;Session,Donna R.. 2010. Discontinuation of rLH two days before hCG may increase the number of oocytes retrieved in IVF. Reproductive Biology and Endocrinology 8( ): 29-29.
dc.identifier.issn 1477-7827
dc.identifier.uri http://hdl.handle.net/10161/4369
dc.description.abstract Background: Administration of recombinant luteinizing hormone (rLH) in controlled ovarian hyperstimulation may benefit a subpopulation of patients. However, late follicular phase administration of high doses of rLH may also reduce the size of the follicular cohort and promote monofollicular development. Methods: To determine if rLH in late follicular development had a negative impact on follicular growth and oocyte yield, IVF patients in our practice who received rFSH and rLH for the entire stimulation were retrospectively compared with those that had the rLH discontinued at least two days prior to hCG trigger. Results: The two groups had similar baseline characteristics before stimulation with respect to age, FSH level and antral follicle count. However, the group which had the rLH discontinued at least two days prior to their hCG shot, had a significantly higher number of oocytes retrieved, including a higher number of MII oocytes and number of 2PN embryos. Conclusions: When using rLH for controlled ovarian hyperstimulation, administering it from the start of stimulation and stopping it in the late follicular phase, at least two days prior to hCG trigger, may increase oocyte and embryo yield.
dc.language.iso en_US
dc.publisher BIOMED CENTRAL LTD
dc.relation.isversionof 10.1186/1477-7827-8-29
dc.subject recombinant human lh
dc.subject in-vitro fertilization
dc.subject controlled ovarian
dc.subject stimulation
dc.subject controlled-trial
dc.subject fsh
dc.subject supplementation
dc.subject women
dc.subject multicenter
dc.subject protocol
dc.subject cycles
dc.subject endocrinology & metabolism
dc.subject reproductive biology
dc.title Discontinuation of rLH two days before hCG may increase the number of oocytes retrieved in IVF
dc.title.alternative
dc.type Other article
dc.description.version Version of Record
duke.date.pubdate 2010-3-23
duke.description.issue
duke.description.volume 8
dc.relation.journal Reproductive Biology and Endocrinology
pubs.begin-page 29


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