Oestrogen shuts the door on SOX9.
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Oestrogen exerts a robust yet imperfectly understood effect on sexual development in vertebrate embryos. New work by Pask and colleagues in BMC Biology indicates that it may interfere with male development by preventing nuclear localization of SOX9, a master regulator of the testis differentiation pathway. See research article http://www.biomedcentral.com/1741-7007/8/113.
Published Version (Please cite this version)10.1186/1741-7007-8-110
Publication InfoCapel, Blanche; & Mork, L (2010). Oestrogen shuts the door on SOX9. BMC Biol, 8. pp. 110. 10.1186/1741-7007-8-110. Retrieved from https://hdl.handle.net/10161/4374.
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James B. Duke Distinguished Professor of Cell Biology
In mammals, the primary step in male sex determination is the initiation of testis development in the bipotential gonad primordium. This step depends on the Y-linked male sex-determining gene, Sry. Expression of Sry in the XY gonad, or as a transgene in an XX gonad, leads to the differentiation of Sertoli cells. Failures in Sertoli cell differentiation in the XY gonad result in sex reversal and ovary formation. In addition to Sertoli cell differentiation, we are studying the s