Oestrogen shuts the door on SOX9.
Abstract
Oestrogen exerts a robust yet imperfectly understood effect on sexual development
in vertebrate embryos. New work by Pask and colleagues in BMC Biology indicates that
it may interfere with male development by preventing nuclear localization of SOX9,
a master regulator of the testis differentiation pathway. See research article http://www.biomedcentral.com/1741-7007/8/113.
Type
Journal articlePermalink
https://hdl.handle.net/10161/4374Published Version (Please cite this version)
10.1186/1741-7007-8-110Publication Info
(2010). Oestrogen shuts the door on SOX9. BMC Biol, 8. pp. 110. 10.1186/1741-7007-8-110. Retrieved from https://hdl.handle.net/10161/4374.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
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Show full item recordScholars@Duke
Blanche Capel
James B. Duke Distinguished Professor of Cell Biology
In mammals, the primary step in male sex determination is the initiation of testis
development in the bipotential gonad primordium. This step depends on the Y-linked
male sex-determining gene, Sry. Expression of Sry in the XY gonad, or as a transgene
in an XX gonad, leads to the differentiation of Sertoli cells. Failures in Sertoli
cell differentiation in the XY gonad result in sex reversal and ovary formation. In
addition to Sertoli cell differentiation, we are studying the s
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