Calorie restriction and endurance exercise share potent anti-inflammatory function in adipose tissues in ameliorating diet-induced obesity and insulin resistance in mice
Abstract
Background: Calorie restriction (CR) and endurance exercise are known to attenuate
obesity and improve the metabolic syndrome. The aim of this study was to directly
compare the effects of CR and endurance exercise in a mouse model of diet-induced
obesity and insulin resistance. Methods: Adult male C57BL/6N mice were randomly assigned
and subjected to one of the six interventions for 8 weeks: low-fat diet (LC, 10% fat),
low-fat diet with 30% calorie restriction (LR), high-fat diet (HC, 60% fat), high-fat
diet with 30% calorie restriction (HR), high-fat diet with voluntary running exercise
(HE), and high-fat diet with a combination of 30% calorie restriction and exercise
(HRE). The impacts of the interventions were assessed by comprehensive metabolic analyses
and pro-inflammatory cytokine gene expression. Results: Endurance exercise significantly
attenuated high-fat diet-induced obesity. CR dramatically prevented high-fat diet-induced
metabolic abnormalities. A combination of CR and endurance exercise further reduced
obesity and insulin resistance under the condition of high-fat diet. CR and endurance
exercise each potently suppressed the expression of inflammatory cytokines in white
adipose tissues with additive effects when combined, but the effects of diet and exercise
interventions in the liver were moderate to minimal. Conclusions: CR and endurance
exercise share a potent anti-inflammatory function in adipose tissues in ameliorating
diet-induced obesity and insulin resistance.
Type
Other articleSubject
weight-loss programpolyunsaturated fatty-acids
type-2
diabetes-mellitus
c-reactive protein
postmenopausal women
metabolic
syndrome
macrophage infiltration
cytokine production
skeletal-muscle
body-weight
nutrition & dietetics
Permalink
https://hdl.handle.net/10161/4377Published Version (Please cite this version)
10.1186/1743-7075-7-59Citation
Huang,Ping;Li,Shoufeng;Shao,Mengle;Qi,Qibin;Zhao,Feng;You,Jia;Mao,Ting;Li,Wenjun;Yan,Zhen;Liu,Yong.
2010. Calorie restriction and endurance exercise share potent anti-inflammatory function
in adipose tissues in ameliorating diet-induced obesity and insulin resistance in
mice. Nutrition & Metabolism 7( ): 59-59.
Collections
More Info
Show full item record
Articles written by Duke faculty are made available through the campus open access policy. For more information see: Duke Open Access Policy
Rights for Collection: Scholarly Articles
Works are deposited here by their authors, and represent their research and opinions, not that of Duke University. Some materials and descriptions may include offensive content. More info