Ordered structure of the transcription network inherited from the yeast whole-genome duplication
Abstract
Background: Gene duplication, a major evolutionary path to genomic innovation, can
occur at the scale of an entire genome. One such "whole-genome duplication" (WGD)
event among the Ascomycota fungi gave rise to genes with distinct biological properties
compared to small-scale duplications. Results: We studied the evolution of transcriptional
interactions of whole-genome duplicates, to understand how they are wired into the
yeast regulatory system. Our work combines network analysis and modeling of the large-scale
structure of the interactions stemming from the WGD. Conclusions: The results uncover
the WGD as a major source for the evolution of a complex interconnected block of transcriptional
pathways. The inheritance of interactions among WGD duplicates follows elementary
"duplication subgraphs", relating ancestral interactions with newly formed ones. Duplication
subgraphs are correlated with their neighbours and give rise to higher order circuits
with two elementary properties: newly formed transcriptional pathways remain connected
(paths are not broken), and are preferentially cross-connected with ancestral ones.
The result is a coherent and connected "WGD-network", where duplication subgraphs
are arranged in an astonishingly ordered configuration.
Type
Other articleSubject
saccharomyces-cerevisiaeregulatory network
evolution
consequences
aneuploidy
mathematical & computational biology
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https://hdl.handle.net/10161/4387Published Version (Please cite this version)
10.1186/1752-0509-4-77Citation
Fusco,Diana;Grassi,Luigi;Bassetti,Bruno;Caselle,Michele;Lagomarsino,Marco Cosentino.
2010. Ordered structure of the transcription network inherited from the yeast whole-genome
duplication. Bmc Systems Biology 4( ): 77-77.
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