Show simple item record Lantos, Paul en_US Woods, Christopher W. en_US 2011-06-21T17:30:26Z 2011-06-21T17:30:26Z 2010 en_US
dc.identifier.citation Breitschwerdt,Edward B.;Maggi,Ricardo G.;Lantos,Paul M.;Woods,Christopher W.;Hegarty,Barbara C.;Bradley,Julie M.. 2010. Bartonella vinsonii subsp berkhoffii and Bartonella henselae bacteremia in a father and daughter with neurological disease. Parasites & Vectors 3( ): 29-29. en_US
dc.identifier.issn 1756-3305 en_US
dc.description.abstract Background: Bartonella vinsonii subsp. berkhoffii is an important, emerging, intravascular bacterial pathogen that has been recently isolated from immunocompetent patients with endocarditis, arthritis, neurological disease and vasoproliferative neoplasia. Vector transmission is suspected among dogs and wild canines, which are the primary reservoir hosts. This investigation was initiated to determine if pets and family members were infected with one or more Bartonella species. Methods: PCR and enrichment blood culture in Bartonella alpha Proteobacteria growth medium (BAPGM) was used to determine infection status. Antibody titers to B. vinsonii subsp. berkhoffii genotypes I-III and B. henselae were determined using a previously described indirect fluorescent antibody test. Two patients were tested sequentially for over a year to assess the response to antibiotic treatment. Results: Intravascular infection with B. vinsonii subsp. berkhoffii genotype II and Bartonella henselae (Houston 1 strain) were confirmed in a veterinarian and his daughter by enrichment blood culture, followed by PCR and DNA sequencing. Symptoms included progressive weight loss, muscle weakness, lack of coordination (the father) and headaches, muscle pain and insomnia (the daughter). B. vinsonii subsp. berkhoffii genotype II was also sequenced from a cerebrospinal fluid BAPGM enrichment culture and from a periodontal swab sample. After repeated courses of antibiotics, post-treatment blood cultures were negative, there was a decremental decrease in antibody titers to non-detectable levels and symptoms resolved in both patients. Conclusions: B. vinsonii subsp. berkhoffii and B. henselae are zoonotic pathogens that can be isolated from the blood of immunocompetent family members with arthralgias, fatigue and neurological symptoms. Therapeutic elimination of Bartonella spp. infections can be challenging, and follow-up testing is recommended. An increasing number of arthropod vectors, including biting flies, fleas, keds, lice, sandflies and ticks have been confirmed or are suspected as the primary mode of transmission of Bartonella species among animal populations and may also pose a risk to human beings. en_US
dc.language.iso en_US en_US
dc.publisher BIOMED CENTRAL LTD en_US
dc.relation.isversionof doi:10.1186/1756-3305-3-29 en_US
dc.subject cat-scratch disease en_US
dc.subject blood en_US
dc.subject dog en_US
dc.subject infection en_US
dc.subject periodontitis en_US
dc.subject clarridgeiae en_US
dc.subject endocarditis en_US
dc.subject prevalence en_US
dc.subject quintana en_US
dc.subject pets en_US
dc.subject parasitology en_US
dc.title Bartonella vinsonii subsp berkhoffii and Bartonella henselae bacteremia in a father and daughter with neurological disease en_US
dc.title.alternative en_US
dc.description.version Version of Record en_US 2010-4-8 en_US
duke.description.endpage 29 en_US
duke.description.issue en_US
duke.description.startpage 29 en_US
duke.description.volume 3 en_US
dc.relation.journal Parasites & Vectors en_US

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