Common genetic variation and the control of HIV-1 in humans.
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To extend the understanding of host genetic determinants of HIV-1 control, we performed a genome-wide association study in a cohort of 2,554 infected Caucasian subjects. The study was powered to detect common genetic variants explaining down to 1.3% of the variability in viral load at set point. We provide overwhelming confirmation of three associations previously reported in a genome-wide study and show further independent effects of both common and rare variants in the Major Histocompatibility Complex region (MHC). We also examined the polymorphisms reported in previous candidate gene studies and fail to support a role for any variant outside of the MHC or the chemokine receptor cluster on chromosome 3. In addition, we evaluated functional variants, copy-number polymorphisms, epistatic interactions, and biological pathways. This study thus represents a comprehensive assessment of common human genetic variation in HIV-1 control in Caucasians.
Major Histocompatibility Complex
Polymorphism, Single Nucleotide
Published Version (Please cite this version)10.1371/journal.pgen.1000791
Publication InfoFellay, Jacques; Ge, Dongliang; Shianna, Kevin V; Colombo, Sara; Ledergerber, Bruno; Cirulli, Elizabeth T; ... NIAID Center for HIV/AIDS Vaccine Immunology (CHAVI) (2009). Common genetic variation and the control of HIV-1 in humans. PLoS Genet, 5(12). pp. e1000791. 10.1371/journal.pgen.1000791. Retrieved from https://hdl.handle.net/10161/4457.
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Adjunct Assistant Prof in the Department of Molecular Genetics and Microbiology
Liz is interested in the genetics underlying normal variation in healthy humans, with a focus on traits relevant to disease and involving neuronal function, for example cognitive performance, face recognition, and time perception. She is also interested in applying genome sequencing for disease gene discovery and in studying people with extreme traits, such as those living to at least 100 years of age.
Adjunct Professor in the Department of Molecular Genetics and Microbiology
Frederic M. Hanes Distinguished Professor of Medicine
The Haynes lab is studying host innate and adaptive immune responses to the human immunodeficiency virus (HIV), tuberculosis (TB), and influenza in order to find the enabling technology to make preventive vaccines against these three major infectious diseases. Mucosal Immune Responses in Acute HIV Infection The Haynes lab is working to determine why broadly neutralizing antibodies are rarely made in acute HIV infection (AHI), currently a major obstacle in the de
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