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Common genetic variation and the control of HIV-1 in humans.

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Date
2009-12
Authors
Fellay, Jacques
Ge, Dongliang
Shianna, Kevin V
Colombo, Sara
Ledergerber, Bruno
Cirulli, Elizabeth T
Urban, Thomas J
Zhang, Kunlin
Gumbs, Curtis E
Smith, Jason P
Castagna, Antonella
Cozzi-Lepri, Alessandro
De Luca, Andrea
Easterbrook, Philippa
Günthard, Huldrych F
Mallal, Simon
Mussini, Cristina
Dalmau, Judith
Martinez-Picado, Javier
Miro, José M
Obel, Niels
Wolinsky, Steven M
Martinson, Jeremy J
Detels, Roger
Margolick, Joseph B
Jacobson, Lisa P
Descombes, Patrick
Antonarakis, Stylianos E
Beckmann, Jacques S
O'Brien, Stephen J
Letvin, Norman L
McMichael, Andrew J
Haynes, Barton F
Carrington, Mary
Feng, Sheng
Telenti, Amalio
Goldstein, David B
NIAID Center for HIV/AIDS Vaccine Immunology (CHAVI)
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Abstract
To extend the understanding of host genetic determinants of HIV-1 control, we performed a genome-wide association study in a cohort of 2,554 infected Caucasian subjects. The study was powered to detect common genetic variants explaining down to 1.3% of the variability in viral load at set point. We provide overwhelming confirmation of three associations previously reported in a genome-wide study and show further independent effects of both common and rare variants in the Major Histocompatibility Complex region (MHC). We also examined the polymorphisms reported in previous candidate gene studies and fail to support a role for any variant outside of the MHC or the chemokine receptor cluster on chromosome 3. In addition, we evaluated functional variants, copy-number polymorphisms, epistatic interactions, and biological pathways. This study thus represents a comprehensive assessment of common human genetic variation in HIV-1 control in Caucasians.
Type
Journal article
Subject
Adult
Alleles
Disease Progression
Female
Genetic Variation
Genotype
HIV Infections
HIV-1
Humans
Kaplan-Meier Estimate
Major Histocompatibility Complex
Male
Phenotype
Polymorphism, Single Nucleotide
Viral Load
Permalink
https://hdl.handle.net/10161/4457
Published Version (Please cite this version)
10.1371/journal.pgen.1000791
Publication Info
Fellay, Jacques; Ge, Dongliang; Shianna, Kevin V; Colombo, Sara; Ledergerber, Bruno; Cirulli, Elizabeth T; ... NIAID Center for HIV/AIDS Vaccine Immunology (CHAVI) (2009). Common genetic variation and the control of HIV-1 in humans. PLoS Genet, 5(12). pp. e1000791. 10.1371/journal.pgen.1000791. Retrieved from https://hdl.handle.net/10161/4457.
This is constructed from limited available data and may be imprecise. To cite this article, please review & use the official citation provided by the journal.
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Scholars@Duke

David Benjamin Goldstein

Adjunct Professor in the Department of Molecular Genetics and Microbiology
Haynes

Barton Ford Haynes

Frederic M. Hanes Distinguished Professor of Medicine
The Haynes lab is studying host innate and adaptive immune responses to the human immunodeficiency virus (HIV), tuberculosis (TB), and influenza in order to find the enabling technology to make preventive vaccines against these three major infectious diseases. Mucosal Immune Responses in Acute HIV Infection The Haynes lab is working to determine why broadly neutralizing antibodies are rarely made in acute HIV infection (AHI), currently a major obstacle in the de
Alphabetical list of authors with Scholars@Duke profiles.
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