Common genetic variation and the control of HIV-1 in humans.
Abstract
To extend the understanding of host genetic determinants of HIV-1 control, we performed
a genome-wide association study in a cohort of 2,554 infected Caucasian subjects.
The study was powered to detect common genetic variants explaining down to 1.3% of
the variability in viral load at set point. We provide overwhelming confirmation of
three associations previously reported in a genome-wide study and show further independent
effects of both common and rare variants in the Major Histocompatibility Complex region
(MHC). We also examined the polymorphisms reported in previous candidate gene studies
and fail to support a role for any variant outside of the MHC or the chemokine receptor
cluster on chromosome 3. In addition, we evaluated functional variants, copy-number
polymorphisms, epistatic interactions, and biological pathways. This study thus represents
a comprehensive assessment of common human genetic variation in HIV-1 control in Caucasians.
Type
Journal articleSubject
AdultAlleles
Disease Progression
Female
Genetic Variation
Genotype
HIV Infections
HIV-1
Humans
Kaplan-Meier Estimate
Major Histocompatibility Complex
Male
Phenotype
Polymorphism, Single Nucleotide
Viral Load
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https://hdl.handle.net/10161/4457Published Version (Please cite this version)
10.1371/journal.pgen.1000791Publication Info
Fellay, Jacques; Ge, Dongliang; Shianna, Kevin V; Colombo, Sara; Ledergerber, Bruno;
Cirulli, Elizabeth T; ... NIAID Center for HIV/AIDS Vaccine Immunology (CHAVI) (2009). Common genetic variation and the control of HIV-1 in humans. PLoS Genet, 5(12). pp. e1000791. 10.1371/journal.pgen.1000791. Retrieved from https://hdl.handle.net/10161/4457.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
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Show full item recordScholars@Duke
David Benjamin Goldstein
Adjunct Professor in the Department of Molecular Genetics and Microbiology
Barton Ford Haynes
Frederic M. Hanes Distinguished Professor of Medicine
Barton F. Haynes, M.D. is the Frederic M. Hanes Professor of Medicine and Immunology,
and Director of the Duke Human Vaccine Institute. Prior to leading the DHVI, Dr. Haynes
served as Chief of the Division of Rheumatology, Allergy and Clinical Immunology,
and later as Chair of the Department of Medicine. As Director of the Duke Human Vaccine
Institute, Bart Haynes is leading a team of investigators working on vaccines for
emerging infections, including tuberculosis, pandemic influenza, emergi
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