Show simple item record Fellay, J Ge, D Shianna, KV Colombo, S Ledergerber, B Cirulli, ET Urban, TJ Zhang, K Gumbs, CE Smith, JP Castagna, A Cozzi-Lepri, A De Luca, A Easterbrook, P Günthard, HF Mallal, S Mussini, C Dalmau, J Martinez-Picado, J Miro, JM Obel, N Wolinsky, SM Martinson, JJ Detels, R Margolick, JB Jacobson, LP Descombes, P Antonarakis, SE Beckmann, JS O'Brien, SJ Letvin, NL McMichael, AJ Haynes, BF Carrington, M Feng, S Telenti, A Goldstein, DB NIAID Center for HIV/AIDS Vaccine Immunology (CHAVI)
dc.coverage.spatial United States 2011-06-21T17:31:15Z 2009-12
dc.identifier.citation PLoS Genet, 2009, 5 (12), pp. e1000791 - ?
dc.description.abstract To extend the understanding of host genetic determinants of HIV-1 control, we performed a genome-wide association study in a cohort of 2,554 infected Caucasian subjects. The study was powered to detect common genetic variants explaining down to 1.3% of the variability in viral load at set point. We provide overwhelming confirmation of three associations previously reported in a genome-wide study and show further independent effects of both common and rare variants in the Major Histocompatibility Complex region (MHC). We also examined the polymorphisms reported in previous candidate gene studies and fail to support a role for any variant outside of the MHC or the chemokine receptor cluster on chromosome 3. In addition, we evaluated functional variants, copy-number polymorphisms, epistatic interactions, and biological pathways. This study thus represents a comprehensive assessment of common human genetic variation in HIV-1 control in Caucasians.
dc.format.extent e1000791 - ?
dc.language eng
dc.language.iso en_US en_US
dc.relation.ispartof PLoS Genet
dc.relation.isversionof 10.1371/journal.pgen.1000791
dc.subject Adult
dc.subject Alleles
dc.subject Disease Progression
dc.subject Female
dc.subject Genetic Variation
dc.subject Genotype
dc.subject HIV Infections
dc.subject HIV-1
dc.subject Humans
dc.subject Kaplan-Meier Estimate
dc.subject Major Histocompatibility Complex
dc.subject Male
dc.subject Phenotype
dc.subject Polymorphism, Single Nucleotide
dc.subject Viral Load
dc.title Common genetic variation and the control of HIV-1 in humans.
dc.title.alternative en_US
dc.type Journal Article
dc.description.version Version of Record en_US 2009-12-0 en_US
duke.description.endpage e1000791 en_US
duke.description.issue 12 en_US
duke.description.startpage e1000791 en_US
duke.description.volume 5 en_US
dc.relation.journal Plos Genetics en_US
pubs.issue 12
pubs.organisational-group /Duke
pubs.organisational-group /Duke/Institutes and Provost's Academic Units
pubs.organisational-group /Duke/Institutes and Provost's Academic Units/University Institutes and Centers
pubs.organisational-group /Duke/Institutes and Provost's Academic Units/University Institutes and Centers/Duke Institute for Brain Sciences
pubs.organisational-group /Duke/Institutes and Provost's Academic Units/University Institutes and Centers/Global Health Institute
pubs.organisational-group /Duke/School of Medicine
pubs.organisational-group /Duke/School of Medicine/Basic Science Departments
pubs.organisational-group /Duke/School of Medicine/Basic Science Departments/Immunology
pubs.organisational-group /Duke/School of Medicine/Basic Science Departments/Molecular Genetics and Microbiology
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments/Medicine
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments/Medicine/Medicine, Duke Human Vaccine Institute
pubs.organisational-group /Duke/School of Medicine/Institutes and Centers
pubs.organisational-group /Duke/School of Medicine/Institutes and Centers/Duke Cancer Institute
pubs.organisational-group /Duke/School of Medicine/Institutes and Centers/Duke Center for Human Genome Variation
pubs.organisational-group /Duke/School of Medicine/Institutes and Centers/Duke Clinical Research Institute
pubs.organisational-group /Duke/School of Medicine/Institutes and Centers/Duke Human Vaccine Institute
pubs.publication-status Published
pubs.volume 5
dc.identifier.eissn 1553-7404

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