Molecular Poltergeists: Mitochondrial DNA Copies (numts) in Sequenced Nuclear Genomes
Repository Usage Stats
The natural transfer of DNA from mitochondria to the nucleus generates nuclear copies of mitochondrial DNA (numts) and is an ongoing evolutionary process, as genome sequences attest. In humans, five different numts cause genetic disease and a dozen human loci are polymorphic for the presence of numts, underscoring the rapid rate at which mitochondrial sequences reach the nucleus over evolutionary time. In the laboratory and in nature, numts enter the nuclear DNA via non-homolgous end joining (NHEJ) at double-strand breaks (DSBs). The frequency of numt insertions among 85 sequenced eukaryotic genomes reveal that numt content is strongly correlated with genome size, suggesting that the numt insertion rate might be limited by DSB frequency. Polymorphic numts in humans link maternally inherited mitochondrial genotypes to nuclear DNA haplotypes during the past, offering new opportunities to associate nuclear markers with mitochondrial markers back in time.
genetics & heredity
Published Version (Please cite this version)10.1371/journal.pgen.1000834
CitationHazkani-Covo,Einat;Zeller,Raymond M.;Martin,William. 2010. Molecular Poltergeists: Mitochondrial DNA Copies (numts) in Sequenced Nuclear Genomes. Plos Genetics 6(2): e1000834-e1000834.
More InfoShow full item record
Articles written by Duke faculty are made available through the campus open access policy. For more information see: Duke Open Access Policy
Rights for Collection: Scholarly Articles
Works are deposited here by their authors, and represent their research and opinions, not that of Duke University. Some materials and descriptions may include offensive content. More info