Show simple item record

Molecular Poltergeists: Mitochondrial DNA Copies (numts) in Sequenced Nuclear Genomes

dc.contributor.author Zeller, Raymond M
dc.date.accessioned 2011-06-21T17:31:16Z
dc.date.available 2011-06-21T17:31:16Z
dc.date.issued 2010
dc.identifier.citation Hazkani-Covo,Einat;Zeller,Raymond M.;Martin,William. 2010. Molecular Poltergeists: Mitochondrial DNA Copies (numts) in Sequenced Nuclear Genomes. Plos Genetics 6(2): e1000834-e1000834.
dc.identifier.issn 1553-7390
dc.identifier.uri http://hdl.handle.net/10161/4462
dc.description.abstract The natural transfer of DNA from mitochondria to the nucleus generates nuclear copies of mitochondrial DNA (numts) and is an ongoing evolutionary process, as genome sequences attest. In humans, five different numts cause genetic disease and a dozen human loci are polymorphic for the presence of numts, underscoring the rapid rate at which mitochondrial sequences reach the nucleus over evolutionary time. In the laboratory and in nature, numts enter the nuclear DNA via non-homolgous end joining (NHEJ) at double-strand breaks (DSBs). The frequency of numt insertions among 85 sequenced eukaryotic genomes reveal that numt content is strongly correlated with genome size, suggesting that the numt insertion rate might be limited by DSB frequency. Polymorphic numts in humans link maternally inherited mitochondrial genotypes to nuclear DNA haplotypes during the past, offering new opportunities to associate nuclear markers with mitochondrial markers back in time.
dc.language.iso en_US
dc.publisher PUBLIC LIBRARY SCIENCE
dc.relation.isversionof 10.1371/journal.pgen.1000834
dc.subject yeast saccharomyces-cerevisiae
dc.subject human genetic-disease
dc.subject double-strand
dc.subject breaks
dc.subject promiscuous dna
dc.subject organelle dna
dc.subject domestic cat
dc.subject evolution
dc.subject pseudogenes
dc.subject insertions
dc.subject chromosomes
dc.subject genetics & heredity
dc.title Molecular Poltergeists: Mitochondrial DNA Copies (numts) in Sequenced Nuclear Genomes
dc.title.alternative
dc.type Other article
dc.description.version Version of Record
duke.date.pubdate 2010-2-0
duke.description.issue 2
duke.description.volume 6
dc.relation.journal Plos Genetics
pubs.begin-page e1000834


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record