Duke University Libraries
View Item 
  •   DukeSpace
  • Duke Scholarly Works
  • Scholarly Articles
  • View Item
  •   DukeSpace
  • Duke Scholarly Works
  • Scholarly Articles
  • View Item
    • Login
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    The scale of population structure in Arabidopsis thaliana.

    Thumbnail
    View / Download
    442.9 Kb
    Date
    2010-02-12
    Authors
    Agren, J
    Anastasio, AE
    Bergelson, J
    Borevitz, JO
    Bossdorf, O
    Byers, D
    Donohue, Kathleen
    Dunning, M
    Holub, EB
    Horton, M
    Huang, YS
    Hudson, A
    Le Corre, V
    Li, Y
    Loudet, O
    Mulyati, NW
    Nordborg, M
    Platt, A
    Rivero, L
    Roux, F
    Scholl, R
    Warthmann, N
    Weigel, D
    Show More
    (23 total)
    Repository Usage Stats
    242
    views
    123
    downloads
    Abstract
    The population structure of an organism reflects its evolutionary history and influences its evolutionary trajectory. It constrains the combination of genetic diversity and reveals patterns of past gene flow. Understanding it is a prerequisite for detecting genomic regions under selection, predicting the effect of population disturbances, or modeling gene flow. This paper examines the detailed global population structure of Arabidopsis thaliana. Using a set of 5,707 plants collected from around the globe and genotyped at 149 SNPs, we show that while A. thaliana as a species self-fertilizes 97% of the time, there is considerable variation among local groups. This level of outcrossing greatly limits observed heterozygosity but is sufficient to generate considerable local haplotypic diversity. We also find that in its native Eurasian range A. thaliana exhibits continuous isolation by distance at every geographic scale without natural breaks corresponding to classical notions of populations. By contrast, in North America, where it exists as an exotic species, A. thaliana exhibits little or no population structure at a continental scale but local isolation by distance that extends hundreds of km. This suggests a pattern for the development of isolation by distance that can establish itself shortly after an organism fills a new habitat range. It also raises questions about the general applicability of many standard population genetics models. Any model based on discrete clusters of interchangeable individuals will be an uneasy fit to organisms like A. thaliana which exhibit continuous isolation by distance on many scales.
    Type
    Journal article
    Subject
    Alleles
    Arabidopsis
    Crosses, Genetic
    Geography
    Haplotypes
    Heterozygote
    Inbreeding
    Population Dynamics
    Permalink
    http://hdl.handle.net/10161/4463
    Published Version (Please cite this version)
    10.1371/journal.pgen.1000843
    Publication Info
    Agren, J; Anastasio, AE; Bergelson, J; Borevitz, JO; Bossdorf, O; Byers, D; ... Weigel, D (2010). The scale of population structure in Arabidopsis thaliana. PLoS Genet, 6(2). pp. e1000843. 10.1371/journal.pgen.1000843. Retrieved from http://hdl.handle.net/10161/4463.
    This is constructed from limited available data and may be imprecise. To cite this article, please review & use the official citation provided by the journal.
    Collections
    • Scholarly Articles
    More Info
    Show full item record

    Scholars@Duke

    Donohue

    Kathleen Donohue

    Professor of Biology
    We investigate the genetic basis of adaptation, including the evolution of phenotypic plasticity and maternal effects, the adaptive value of epigenetic modifications, niche construction, dispersal, and mechanisms of multilevel natural selection.
    Platt

    Alyssa Platt

    Biostatistician II
    Education: Masters Degree, Applied Economics.  Duke University. 2007Bachelors Degree, Economics and Mathematics.  University of North Carolina at GreensboroOverview: Alyssa has ongoing collaborations with faculty from Duke Global Health Institute. Her professional experience involves analysis and evaluation of health policy in areas of obesity, physical activity and nutrition, health care access, and infectious disease. She is experienced in longitudinal and cros
    Alphabetical list of authors with Scholars@Duke profiles.
    Open Access

    Articles written by Duke faculty are made available through the campus open access policy. For more information see: Duke Open Access Policy

    Rights for Collection: Scholarly Articles

     

     

    Browse

    All of DukeSpaceCommunities & CollectionsAuthorsTitlesTypesBy Issue DateDepartmentsAffiliations of Duke Author(s)SubjectsBy Submit DateThis CollectionAuthorsTitlesTypesBy Issue DateDepartmentsAffiliations of Duke Author(s)SubjectsBy Submit Date

    My Account

    LoginRegister

    Statistics

    View Usage Statistics