Show simple item record Platt, A Horton, M Huang, YS Li, Y Anastasio, AE Mulyati, NW Agren, J Bossdorf, O Byers, D Donohue, K Dunning, M Holub, EB Hudson, A Le Corre, V Loudet, O Roux, F Warthmann, N Weigel, D Rivero, L Scholl, R Nordborg, M Bergelson, J Borevitz, JO
dc.coverage.spatial United States 2011-06-21T17:31:16Z 2010-02-12
dc.identifier.citation PLoS Genet, 2010, 6 (2), pp. e1000843 - ?
dc.description.abstract The population structure of an organism reflects its evolutionary history and influences its evolutionary trajectory. It constrains the combination of genetic diversity and reveals patterns of past gene flow. Understanding it is a prerequisite for detecting genomic regions under selection, predicting the effect of population disturbances, or modeling gene flow. This paper examines the detailed global population structure of Arabidopsis thaliana. Using a set of 5,707 plants collected from around the globe and genotyped at 149 SNPs, we show that while A. thaliana as a species self-fertilizes 97% of the time, there is considerable variation among local groups. This level of outcrossing greatly limits observed heterozygosity but is sufficient to generate considerable local haplotypic diversity. We also find that in its native Eurasian range A. thaliana exhibits continuous isolation by distance at every geographic scale without natural breaks corresponding to classical notions of populations. By contrast, in North America, where it exists as an exotic species, A. thaliana exhibits little or no population structure at a continental scale but local isolation by distance that extends hundreds of km. This suggests a pattern for the development of isolation by distance that can establish itself shortly after an organism fills a new habitat range. It also raises questions about the general applicability of many standard population genetics models. Any model based on discrete clusters of interchangeable individuals will be an uneasy fit to organisms like A. thaliana which exhibit continuous isolation by distance on many scales.
dc.format.extent e1000843 - ?
dc.language eng
dc.language.iso en_US en_US
dc.relation.ispartof PLoS Genet
dc.relation.isversionof 10.1371/journal.pgen.1000843
dc.subject Alleles
dc.subject Arabidopsis
dc.subject Crosses, Genetic
dc.subject Geography
dc.subject Haplotypes
dc.subject Heterozygote
dc.subject Inbreeding
dc.subject Population Dynamics
dc.title The scale of population structure in Arabidopsis thaliana.
dc.title.alternative en_US
dc.type Journal Article
dc.description.version Version of Record en_US 2010-2-0 en_US
duke.description.endpage e1000843 en_US
duke.description.issue 2 en_US
duke.description.startpage e1000843 en_US
duke.description.volume 6 en_US
dc.relation.journal Plos Genetics en_US
pubs.issue 2
pubs.organisational-group /Duke
pubs.organisational-group /Duke/Trinity College of Arts & Sciences
pubs.organisational-group /Duke/Trinity College of Arts & Sciences/Biology
pubs.publication-status Published online
pubs.volume 6
dc.identifier.eissn 1553-7404

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