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Hippocampus shape analysis and late-life depression.

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Date
2008-03-19
Authors
Zhao, Zheen
Taylor, Warren D
Styner, Martin
Steffens, David C
Krishnan, K Ranga R
MacFall, James R
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Abstract
Major depression in the elderly is associated with brain structural changes and vascular lesions. Changes in the subcortical regions of the limbic system have also been noted. Studies examining hippocampus volumetric differences in depression have shown variable results, possibly due to any volume differences being secondary to local shape changes rather than differences in the overall volume. Shape analysis offers the potential to detect such changes. The present study applied spherical harmonic (SPHARM) shape analysis to the left and right hippocampi of 61 elderly subjects with major depression and 43 non-depressed elderly subjects. Statistical models controlling for age, sex, and total cerebral volume showed a significant reduction in depressed compared with control subjects in the left hippocampus (F(1,103) = 5.26; p = 0.0240) but not right hippocampus volume (F(1,103) = 0.41; p = 0.5213). Shape analysis showed significant differences in the mid-body of the left (but not the right) hippocampus between depressed and controls. When the depressed group was dichotomized into those whose depression was remitted at time of imaging and those who were unremitted, the shape comparison showed remitted subjects to be indistinguishable from controls (both sides) while the unremitted subjects differed in the midbody and the lateral side near the head. Hippocampal volume showed no difference between controls and remitted subjects but nonremitted subjects had significantly smaller left hippocampal volumes with no significant group differences in the right hippocampus. These findings may provide support to other reports of neurogenic effects of antidepressants and their relation to successful treatment for depressive symptoms.
Type
Journal article
Subject
Age of Onset
Aged
Depression
Hippocampus
Humans
Magnetic Resonance Imaging
Permalink
https://hdl.handle.net/10161/4485
Published Version (Please cite this version)
10.1371/journal.pone.0001837
Publication Info
Zhao, Zheen; Taylor, Warren D; Styner, Martin; Steffens, David C; Krishnan, K Ranga R; & MacFall, James R (2008). Hippocampus shape analysis and late-life depression. PLoS One, 3(3). pp. e1837. 10.1371/journal.pone.0001837. Retrieved from https://hdl.handle.net/10161/4485.
This is constructed from limited available data and may be imprecise. To cite this article, please review & use the official citation provided by the journal.
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Scholars@Duke

Krishnan

K. Ranga Rama Krishnan

Professor Emeritus of Psychiatry and Behavioral Sciences
I have validated in vivo methods of estimating volumes of subcortical structures utilizing MRI and sterology. These studies have suggested that depressed patients have smaller caudate, smaller putamen, altered water balance in the hippocampus, a smaller medulla and cerebellar vermis, and enlarged ventricles. Our group has demonstrated that late-life depression patients have increased MRI lesions in the fronto-parietal white matter and subcortical gray; and, have lesions in the caudate inc
MacFall

James R. MacFall

Adjunct Professor in the Department of Radiology
My research centers on application and/or development of image processing and magnetic resonance imaging (MRI) techniques for a variety of biomedical focus areas in Psychiatry, Oncology, Lung Disorders and Pediatric Neurological Disorders:Psychiatry: Research is focused on improving automated methods of brain tissue identification and volume measurement using magnetic resonance images in the context of a study of depression in aging. Similar work is ongoing in b

David Carl Steffens

Professor Emeritus of Psychiatry and Behavioral Sciences
Geriatric Affective Disorders Geriatric Cognitive Disorders Alzheimer's Disease ECT
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