Show simple item record Meadows, SK Dressman, HK Muramoto, GG Himburg, H Salter, A Wei, Z Ginsburg, GS Chao, NJ Nevins, JR Chute, JP
dc.coverage.spatial United States 2011-06-21T17:31:23Z 2008-04-02
dc.identifier.citation PLoS One, 2008, 3 (4), pp. e1912 - ?
dc.description.abstract BACKGROUND: Previous work has demonstrated the potential for peripheral blood (PB) gene expression profiling for the detection of disease or environmental exposures. METHODS AND FINDINGS: We have sought to determine the impact of several variables on the PB gene expression profile of an environmental exposure, ionizing radiation, and to determine the specificity of the PB signature of radiation versus other genotoxic stresses. Neither genotype differences nor the time of PB sampling caused any lessening of the accuracy of PB signatures to predict radiation exposure, but sex difference did influence the accuracy of the prediction of radiation exposure at the lowest level (50 cGy). A PB signature of sepsis was also generated and both the PB signature of radiation and the PB signature of sepsis were found to be 100% specific at distinguishing irradiated from septic animals. We also identified human PB signatures of radiation exposure and chemotherapy treatment which distinguished irradiated patients and chemotherapy-treated individuals within a heterogeneous population with accuracies of 90% and 81%, respectively. CONCLUSIONS: We conclude that PB gene expression profiles can be identified in mice and humans that are accurate in predicting medical conditions, are specific to each condition and remain highly accurate over time.
dc.format.extent e1912 - ?
dc.language eng
dc.language.iso en_US en_US
dc.relation.ispartof PLoS One
dc.relation.isversionof 10.1371/journal.pone.0001912
dc.relation.isreplacedby 10161/13546
dc.subject Animals
dc.subject Endotoxins
dc.subject Environmental Exposure
dc.subject Female
dc.subject Gene Expression Profiling
dc.subject Gene Expression Regulation
dc.subject Humans
dc.subject Lipopolysaccharides
dc.subject Male
dc.subject Mice
dc.subject Mice, Inbred BALB C
dc.subject Mice, Inbred C57BL
dc.subject Radiation Tolerance
dc.subject Radiation, Ionizing
dc.subject Reproducibility of Results
dc.title Gene expression signatures of radiation response are specific, durable and accurate in mice and humans.
dc.title.alternative en_US
dc.type Journal Article
dc.description.version Version of Record en_US 2008-4-2 en_US
duke.description.endpage e1912 en_US
duke.description.issue 4 en_US
duke.description.startpage e1912 en_US
duke.description.volume 3 en_US
dc.relation.journal Plos One en_US
pubs.issue 4
pubs.organisational-group /Duke
pubs.organisational-group /Duke/Faculty
pubs.organisational-group /Duke/Institutes and Provost's Academic Units
pubs.organisational-group /Duke/Institutes and Provost's Academic Units/University Institutes and Centers
pubs.organisational-group /Duke/Institutes and Provost's Academic Units/University Institutes and Centers/Global Health Institute
pubs.organisational-group /Duke/Pratt School of Engineering
pubs.organisational-group /Duke/Pratt School of Engineering/Biomedical Engineering
pubs.organisational-group /Duke/School of Medicine
pubs.organisational-group /Duke/School of Medicine/Basic Science Departments
pubs.organisational-group /Duke/School of Medicine/Basic Science Departments/Immunology
pubs.organisational-group /Duke/School of Medicine/Basic Science Departments/Molecular Genetics and Microbiology
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments/Medicine
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments/Medicine/Medicine, Cardiology
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments/Medicine/Medicine, Cellular Therapy
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments/Pathology
pubs.organisational-group /Duke/School of Medicine/Institutes and Centers
pubs.organisational-group /Duke/School of Medicine/Institutes and Centers/Duke Cancer Institute
pubs.organisational-group /Duke/School of Nursing
pubs.organisational-group /Duke/School of Nursing/School of Nursing - Secondary Group
pubs.publication-status Published online
pubs.volume 3
dc.identifier.eissn 1932-6203

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