Show simple item record Peedicayil, A Vierkant, RA Hartmann, LC Fridley, BL Fredericksen, ZS White, KL Elliott, EA Phelan, CM Tsai, YY Berchuck, A Iversen, ES Couch, FJ Peethamabaran, P Larson, MC Kalli, KR Kosel, ML Shridhar, V Rider, DN Liebow, M Cunningham, JM Schildkraut, JM Sellers, TA Goode, EL
dc.coverage.spatial United States 2011-06-21T17:31:28Z 2010-01-27
dc.identifier.citation PLoS One, 2010, 5 (1), pp. e8884 - ?
dc.description.abstract BACKGROUND: We previously identified a panel of genes associated with outcome of ovarian cancer. The purpose of the current study was to assess whether variants in these genes correlated with ovarian cancer risk. METHODS AND FINDINGS: Women with and without invasive ovarian cancer (749 cases, 1,041 controls) were genotyped at 136 single nucleotide polymorphisms (SNPs) within 13 candidate genes. Risk was estimated for each SNP and for overall variation within each gene. At the gene-level, variation within MSL1 (male-specific lethal-1 homolog) was associated with risk of serous cancer (p = 0.03); haplotypes within PRPF31 (PRP31 pre-mRNA processing factor 31 homolog) were associated with risk of invasive disease (p = 0.03). MSL1 rs7211770 was associated with decreased risk of serous disease (OR 0.81, 95% CI 0.66-0.98; p = 0.03). SNPs in MFSD7, BTN3A3, ZNF200, PTPRS, and CCND1A were inversely associated with risk (p<0.05), and there was increased risk at HEXIM1 rs1053578 (p = 0.04, OR 1.40, 95% CI 1.02-1.91). CONCLUSIONS: Tumor studies can reveal novel genes worthy of follow-up for cancer susceptibility. Here, we found that inherited markers in the gene encoding MSL1, part of a complex that modifies the histone H4, may decrease risk of invasive serous ovarian cancer.
dc.format.extent e8884 - ?
dc.language eng
dc.language.iso en_US en_US
dc.relation.ispartof PLoS One
dc.relation.isversionof 10.1371/journal.pone.0008884
dc.subject Aged
dc.subject Case-Control Studies
dc.subject Female
dc.subject Genetic Predisposition to Disease
dc.subject Haplotypes
dc.subject Humans
dc.subject Middle Aged
dc.subject Ovarian Neoplasms
dc.subject Polymorphism, Single Nucleotide
dc.subject Recurrence
dc.title Risk of ovarian cancer and inherited variants in relapse-associated genes.
dc.title.alternative en_US
dc.type Journal Article
dc.description.version Version of Record en_US 2010-1-27 en_US
duke.description.endpage e8884 en_US
duke.description.issue 1 en_US
duke.description.startpage e8884 en_US
duke.description.volume 5 en_US
dc.relation.journal Plos One en_US
pubs.issue 1
pubs.organisational-group /Duke
pubs.organisational-group /Duke/School of Medicine
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments/Community and Family Medicine
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments/Community and Family Medicine/Community and Family Medicine, Prevention Research
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments/Obstetrics and Gynecology
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments/Obstetrics and Gynecology/Obstetrics and Gynecology, Gynecologic Oncology
pubs.organisational-group /Duke/School of Medicine/Institutes and Centers
pubs.organisational-group /Duke/School of Medicine/Institutes and Centers/Duke Cancer Institute
pubs.organisational-group /Duke/Trinity College of Arts & Sciences
pubs.organisational-group /Duke/Trinity College of Arts & Sciences/Statistical Science
pubs.publication-status Published online
pubs.volume 5
dc.identifier.eissn 1932-6203

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