Show simple item record Lu, Y Futtner, C Rock, JR Xu, X Whitworth, W Hogan, BL Onaitis, MW
dc.coverage.spatial United States 2011-06-21T17:31:31Z 2010-06-10
dc.identifier.citation PLoS One, 2010, 5 (6), pp. e11022 - ?
dc.description.abstract BACKGROUND: SOX2 (Sry-box 2) is required to maintain a variety of stem cells, is overexpressed in some solid tumors, and is expressed in epithelial cells of the lung. METHODOLOGY/PRINCIPAL FINDINGS: We show that SOX2 is overexpressed in human squamous cell lung tumors and some adenocarcinomas. We have generated mouse models in which Sox2 is upregulated in epithelial cells of the lung during development and in the adult. In both cases, overexpression leads to extensive hyperplasia. In the terminal bronchioles, a trachea-like pseudostratified epithelium develops with p63-positive cells underlying columnar cells. Over 12-34 weeks, about half of the mice expressing the highest levels of Sox2 develop carcinoma. These tumors resemble adenocarcinoma but express the squamous marker, Trp63 (p63). CONCLUSIONS: These findings demonstrate that Sox2 overexpression both induces a proximal phenotype in the distal airways/alveoli and leads to cancer.
dc.format.extent e11022 - ?
dc.language eng
dc.language.iso en_US en_US
dc.relation.ispartof PLoS One
dc.relation.isversionof 10.1371/journal.pone.0011022
dc.subject Animals
dc.subject Immunohistochemistry
dc.subject Lung
dc.subject Lung Neoplasms
dc.subject Mice
dc.subject Mice, Transgenic
dc.subject Models, Animal
dc.subject Oncogenes
dc.subject Polymerase Chain Reaction
dc.subject SOXB1 Transcription Factors
dc.title Evidence that SOX2 overexpression is oncogenic in the lung.
dc.title.alternative en_US
dc.type Journal Article
dc.description.version Version of Record en_US 2010-6-10 en_US
duke.description.endpage e11022 en_US
duke.description.issue 6 en_US
duke.description.startpage e11022 en_US
duke.description.volume 5 en_US
dc.relation.journal Plos One en_US
pubs.issue 6
pubs.organisational-group /Duke
pubs.organisational-group /Duke/School of Medicine
pubs.organisational-group /Duke/School of Medicine/Basic Science Departments
pubs.organisational-group /Duke/School of Medicine/Basic Science Departments/Cell Biology
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments/Pediatrics
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments/Surgery
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments/Surgery/Surgery, Cardiovascular and Thoracic Surgery
pubs.organisational-group /Duke/School of Medicine/Institutes and Centers
pubs.organisational-group /Duke/School of Medicine/Institutes and Centers/Duke Cancer Institute
pubs.publication-status Published online
pubs.volume 5
dc.identifier.eissn 1932-6203

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